Association of fungal secondary metabolism and sclerotial biology

Frontiers in Microbiology
Ana M Calvo, J W Cary

Abstract

Fungal secondary metabolism and morphological development have been shown to be intimately associated at the genetic level. Much of the literature has focused on the co-regulation of secondary metabolite production (e.g., sterigmatocystin and aflatoxin in Aspergillus nidulans and Aspergillus flavus, respectively) with conidiation or formation of sexual fruiting bodies. However, many of these genetic links also control sclerotial production. Sclerotia are resistant structures produced by a number of fungal genera. They also represent the principal source of primary inoculum for some phytopathogenic fungi. In nature, higher plants often concentrate secondary metabolites in reproductive structures as a means of defense against herbivores and insects. By analogy, fungi also sequester a number of secondary metabolites in sclerotia that act as a chemical defense system against fungivorous predators. These include antiinsectant compounds such as tetramic acids, indole diterpenoids, pyridones, and diketopiperazines. This chapter will focus on the molecular mechanisms governing production of secondary metabolites and the role they play in sclerotial development and fungal ecology, with particular emphasis on Aspergillus species. The glo...Continue Reading

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Citations

May 6, 2016·Applied Microbiology and Biotechnology·Gerrit Holighaus, Marko Rohlfs
Sep 21, 2016·Fungal Biology·Perng-Kuang ChangJosé Diana Di Mavungu
Nov 8, 2016·Fungal Genetics and Biology : FG & B·Pranav Chettri, Rosie E Bradshaw
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Nov 24, 2019·Applied and Environmental Microbiology·Timothy SatterleeAna M Calvo
May 4, 2018·Ecology and Evolution·Silvia Caballero OrtizMarko Rohlfs
May 23, 2018·Fungal biology and biotechnology·Christoph DattenböckMonika Schmoll
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Dec 12, 2018·Nature Reviews. Microbiology·Nancy P Keller
Jan 25, 2020·Applied Microbiology and Biotechnology·Perng-Kuang ChangMatthew D Lebar
May 30, 2020·Nature Microbiology·Marko Rohlfs

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Methods Mentioned

BETA
sumoylation
gene knockout

Software Mentioned

SMURF
antiSMASH
MIDDAS

Related Concepts

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.