Association of Gastric Acid Suppression and Sorafenib Efficacy in Advanced Hepatocellular Carcinoma.

Journal of Clinical Gastroenterology
Razwan A RazakYuk Ting Ma

Abstract

Recent studies have revealed that coadministration of gastric acid suppressants reduces the efficacy of the tyrosine kinase inhibitors erlotinib and sunitinib in patients with non-small cell lung cancer and renal cell carcinoma, respectively. The authors have therefore assessed if the concurrent use of gastric acid suppressants and sorafenib impairs outcomes in patients with advanced hepatocellular carcinoma (HCC). A retrospective analysis was conducted on all patients treated with sorafenib for advanced HCC at a single tertiary referral unit in the United Kingdom, between January 2008 and January 2014. A multivariate Cox proportional hazard model was used to assess the effect of the concomitant use of gastric acid suppression and sorafenib on progression-free survival (PFS) and overall survival (OS). Data were collected from 197 patients, of which 182 could be assessed for this study; 77 (42%) were on concurrent gastric acid suppression therapy. After adjusting for imbalances between the groups, a Cox regression analysis gave an adjusted hazard ratio for the concurrent acid suppression group compared with the no acid suppression group of 5.4 (95% confidence interval, 3.6-7.9) for PFS and 1.85 (95% confidence interval, 1.3-2.6)...Continue Reading

References

Mar 1, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P Unge, T Andersson
Aug 7, 2002·Clinical Pharmacokinetics·Michael S RobertsMichael Weiss
Mar 1, 1952·Circulation·S E BRADLEYG P BRADLEY
Dec 23, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk StrumbergSiegfried Seeber
Aug 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey W ClarkHeinz-Josef Lenz
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert C KaneRichard Pazdur
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
May 16, 2009·Drug Discovery Today·James M MullinJames J Thornton
Apr 17, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joline S W LindEgbert F Smit
May 2, 2013·Journal of Clinical Gastroenterology·Sahil Mittal, Hashem B El-Serag
Mar 26, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Vincent H HaCarole R Chambers
Feb 10, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roelof W F van LeeuwenRon H J Mathijssen
Jun 25, 2017·Clinical Genitourinary Cancer·Aly-Khan A LalaniToni K Choueiri

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