Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese

Journal of Oral Rehabilitation
J-L XiaoX-C Ma

Abstract

Temporomandibular joint osteoarthritis (TMJOA) is a complex disease and has a strong genetic component in its pathogenesis. Experimental evidence suggests the involvement of biological pathway in the disease. This case-control study was designed to investigate whether five common single nucleotide polymorphisms (SNPs) in GDF5, SMAD3, RUNX2, TGFβ1 and CHST11, respectively, are associated with TMJOA in female Han Chinese patients. A total of 240 participants were evaluated comprising 114 female patients diagnosed with TMJOA based on Research Diagnostic Criteria for Temporomandibular Disorders and 126 healthy female controls. The SNPs of the five genes in the genomic DNA were examined by sequencing, and their allelic, genotypic and carriage rate frequency distributions, as well as the triple combination of the risk genotypes, were analysed using the logistic regression model. The SNP in GDF5 or SMAD3 showed significant association with TMJOA, a relatively weak association was observed in RUNX2. In the triple combinational analysis, the risk of TMJOA grew 5·09 times in the patients with five or six risk alleles (P < 0·01). This is the first study to evaluate the association of GDF5, SMAD3, RUNX2, TGFβ1 and CHST11 with TMJOA in fema...Continue Reading

References

Mar 1, 1996·Nature Genetics·J T ThomasF P Luyten
Sep 1, 1997·Nature Genetics·A PolinkovskyM L Warman
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Rosa Serra, Chenbei Chang
Jan 19, 2007·Nature Reviews. Genetics·Kevin Chen, Nikolaus Rajewsky
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Leslie R HalpernThomas B Dodson
Aug 4, 2009·Cell and Tissue Research·Toshihisa Komori
Nov 28, 2009·Journal of Oral Rehabilitation·O GurbuzE Kurt
May 28, 2010·Arthritis and Rheumatism·Ana M ValdesMichael Doherty
Jul 27, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Bum-Soo KimJihyun Bae
Jan 20, 2011·European Journal of Oral Sciences·Aline C PlanelloAna P de Souza
Jun 7, 2011·Human Molecular Genetics·Louise N ReynardJohn Loughlin
Dec 29, 2011·Frontiers in Bioscience (Scholar Edition)·Kenneth W FinnsonAnie Philip
Jan 11, 2012·Nature Reviews. Rheumatology·Linda J Sandell
Jan 8, 2013·Rheumatology International·Jiang LiyingLi Yujie
May 29, 2013·Nature Reviews. Rheumatology·Emma Leah
Aug 21, 2013·Nature Reviews. Rheumatology·Louise N Reynard, John Loughlin
Sep 26, 2013·Molecular Biology Reports·Dorota FrydeckaAndrzej Kiejna
Feb 1, 2014·Journal of Oral & Facial Pain and Headache·Eric SchiffmanUNKNOWN Orofacial Pain Special Interest Group, International Association for the Study of Pain

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Citations

Oct 27, 2016·Neuroscience·Katerina Zorina-LichtenwalterL Diatchenko
May 17, 2018·Bioscience Reports·Hao-Yu YangHui Zhao
Jan 10, 2018·Journal of Clinical Laboratory Analysis·Li ZhangYou Zhao
Jul 8, 2021·Nature Communications·Pushpanathan MuthuirulanTerence D Capellini

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