Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin

Carcinogenesis
Katie RiddT W Gant

Abstract

Differential gene expression in two established initiation and promotion skin carcinogenesis models during promotion and tumor formation was determined by microarray technology with the purpose of distinguishing the genes more associated with neoplastic transformation from those linked with proliferation and differentiation. The first model utilized dimethylbenz[a]anthracene initiation and 12-O-tetradecanoylphorbol 13-acetate (TPA) promotion in the FVB/N mouse, and the second TPA promotion of the Tg.Ac mouse, which is endogenously initiated by virtue of an activated Ha-ras transgene. Comparison of gene expression profiles across the two models identified genes whose altered expression was associated with papilloma formation rather than TPA-induced proliferation and differentiation. DMBA suppressed TPA-induced differentiation which allowed identification of those genes associated more specifically with differentiation rather than proliferation. EASE (Expression Analysis Systemic Explorer) indicated a correlation between muscle-associated genes and skin differentiation, whereas genes involved with protein biosynthesis were strongly correlated with proliferation. For verification the altered expression of selected genes were confi...Continue Reading

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Citations

Sep 14, 2013·Carcinogenesis·Eduardo Bertoli BelaiAna Paula Campanelli
Oct 28, 2008·Expert Opinion on Drug Metabolism & Toxicology·Alison Hege Harrill, Ivan Rusyn
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