Jul 3, 2015

Association of gene polymorphisms in ABO blood group chromosomal regions and menstrual disorders

Experimental and Therapeutic Medicine
Yong SuZhi-Gang Zhao


This study aimed to investigate whether single nucleotide polymorphisms (SNPs) located near the gene of the ABO blood group play an important role in the genetic aetiology of menstrual disorders (MDs). Polymerase chain reaction-ligase detection reaction technology was used to detect eight SNPs near the ABO gene location on the chromosomes in 250 cases of MD and 250 cases of normal menstruation. The differences in the distribution of each genotype, as well as the allele frequency in the normal and control groups, were analysed using Pearson's χ(2) test to search for disease-associated loci. SHEsis software was used to analyse the linkage disequilibrium and haplotype frequencies and to inspect the correlation between haplotypes and the disease. Compared with the control group, the experimental group exhibited statistically significant differences in the genotype distribution frequencies of the rs657152 locus of the ABO blood group gene and the rs17250673 locus of the tumour necrosis factor cofactor 2 (TRAF2) gene, which is located downstream of the ABO gene. The allele distribution frequencies of rs657152 and rs495828 loci in the ABO blood group gene exhibited significant differences between the groups. Dominant and recessive gen...Continue Reading

  • References18
  • Citations1


  • References18
  • Citations1

Mentioned in this Paper

Computer Software
Gene Polymorphism
Tumor Necrosis Factor-alpha
Menstruation Disturbances
Dysequilibrium Syndrome
Polymerase Chain Reaction Analysis

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