Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma

Journal of Human Genetics
Juan MaChangqing Xu

Abstract

Genetic variations in MDM2, PTEN and P53 might be involved in cancer susceptibility. To assess the contribution of polymorphisms in these three genes to the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population, we genotyped MDM2 T309G, Del1518, PTEN rs701848, rs2735343 and P53 Arg72Pro polymorphisms using PCR-restriction fragment length polymorphism analysis in 226 ESCC cases and 226 cancer-free controls. Here we showed that the risk of ESCC was elevated in subjects with any of the variant genotypes of PTEN rs2735343 and P53 Arg72Pro polymorphisms, but not any genotype of MDM2 or PTEN rs701848. Moreover, multiplicative interactions were observed between PTEN rs2735343 and P53 Arg72Pro or smoking status on risk of ESCC. Our study firstly indicated that PTEN rs2735343 might be a susceptibility factor for ESCC and reaffirmed the role of P53 Arg72Pro in ESCC in this Chinese population, but did not replicate the positive association between MDM2 T309G and ESCC found previously.

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Citations

Mar 19, 2013·Oncogene·J StebbingG Giamas
May 23, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·B ChenX-L Meng
Apr 16, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J Y ChenJ H Fu
May 28, 2013·Biochimica Et Biophysica Acta·Wiljan J A J Hendriks, Rafael Pulido
Nov 7, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X XuL Liu
Jun 3, 2020·Genetics and Molecular Biology·Monyse de NóbregaIlce Mara de Syllos Cólus
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Sukhpreet KaurHarpreet Singh

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