Association of genetic polymorphisms in the telomerase reverse transcriptase gene with prostate cancer aggressiveness

Molecular Medicine Reports
Dapeng WuJian Kang

Abstract

Telomerase reverse transcriptase (TERT), encoded by the TERT gene, is an essential component of telomerase, essential for the maintenance of telomere DNA length, chromosomal stability and cellular immortality. The aim of the present study was to evaluate the association between common genetic variations across the TERT gene region and prostate cancer (PCa) aggressiveness in a Chinese population. A total of 12 TERT tagging single-nucleotide polymorphisms (SNPs) were genotyped on the Sequenom Mass-ARRAY iPLEX® platform in a case-case study with 1,210 Chinese patients with PCa. Unconditional logistic regression was used to investigate the association of genotypes with PCa aggressiveness, Gleason grade and risk of developing early-onset PCa. It was observed that the C allele of the TERT intron 2 SNP (rs2736100) was significantly associated with reduced risk of PCa aggressiveness [odds ratio (OR)=0.81; 95% confidence interval (CI): 0.66-0.99; P=0.037]. This allele was also significantly correlated with a reduced risk of developing a tumor with a high Gleason score (>7; OR=0.83; 95% CI: 0.70-0.99; P=0.039). The T allele of the intron 4 SNP (rs10069690) was found to be significantly associated with a decreased risk for an aggressive f...Continue Reading

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Citations

May 13, 2018·Genes·Tiago Bordeira GasparJoão Vinagre
Oct 27, 2015·Genetic Testing and Molecular Biomarkers·Ayse Tarbin JannuzziGül Özhan
Jul 30, 2016·Cancer Biomarkers : Section a of Disease Markers·Long GongMing Zhou
Sep 21, 2019·Recent Patents on Anti-cancer Drug Discovery·Ying LiuFeng Shi

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