Association of Genetic Polymorphisms of CYP2C9 and VKORC1 with Bleeding Following Warfarin: A Case-Control Study

Current Clinical Pharmacology
Urmila ThatteUrmila M Thatte

Abstract

Various factors have been shown to increase the risk of bleeding with warfarin. This study aimed to assess the association of CYP2C9 and VKORC1 with the development of bleeding following warfarin. A case control study was initiated after obtaining institutional ethics committee clearance and written informed consent from patients. Cases were defined as those who bled within three months of warfarin initiation and controls as those who did not have any episode of bleeding within three months. Genotyping for CYP2C9 (*1, *2, *3) and VKORC1 1639 (GG, GA and AA) was performed by PCRRFLP. Chi square test was used to find out the association and trend of CYP2C9 and VKORC1 genotypes with odds ratio (95% CI) for strength of association. A binary logistic regression model was developed associating age, body weight, sex, CYP2C9 and VKORC1 status with risk of bleeding. A total of 100 controls and 38 cases were studied from Oct 2009 to July 2011. A significant association (P < 0.0001) and trend (P = 0.027) of mutant alleles of CYP2C9 and VKORC1 were noted with bleeding with odds ratios of 7.8 [3.4, 17.9] and 2.7 [1.3, 5.7] respectively. Weekly dose requirement was significantly lower with the presence of *3 allele relative to *1 in CYP2C9 (...Continue Reading

Citations

Aug 20, 2020·Revista latino-americana de enfermagem·Jordana Carvalhaes de MoraesRiccardo Lacchini
Mar 27, 2018·European Journal of Clinical Investigation·María José SernaFrancisco Marín
Apr 28, 2018·Pharmacogenomics·Letícia C TavaresPaulo C J L Santos
Aug 21, 2020·Drug Research·Kannan SridharanAysha Husain
Jul 28, 2018·European Journal of Clinical Pharmacology·Letícia C TavaresPaulo Caleb Junior Lima Santos

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