Association of genetic variability in enzymes metabolizing chemotherapeutic agents with treatment response in head and neck cancer cases

Asia-Pacific Journal of Clinical Oncology
Ankur DhawanDevendra Parmar

Abstract

The prevalence of genetic variants of thiopurine S-methyltransferse (TPMT) and dihydropyrimidine dehydrogenase (DPD) in healthy controls (500) and the treatment response in 500 cases of head and neck cancer of north Indian origin was studied. Blood collected from all the subjects was used for isolation of DNA followed by genotyping studies. The cases received cisplatin and 5-fluorouracil (5-FU) or chemo-radiotherapy and treatment response was measured using WHO criteria. Low frequency of heterozygous mutant genotypes of TPMT*2 (2%), TPMT*3B (2.2%), TPMT*3C (4.6%), DPD IVS14+1G>A (3.6%) and G1601A (3%) was observed, although no homozygous mutants could be identified. Treatment response studies in cases receiving cisplatin and 5-FU or chemo-radiotherapy revealed that the number of nonresponders was higher in cases who carried variant genotypes of TPMT*3B (62.50%) or TPMT*3C (59.26%) or DPD IVS14+1G>A (61.90%). Likewise, the number of nonresponders was still higher in cases carrying combination of these genetic variants. Furthermore, the frequency of nonresponders was higher in cases who carried the variant genotypes of TPMT or DPD and were also tobacco users. Our data clearly show that TPMT and DPD genes are polymorphic in the no...Continue Reading

References

Jul 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·C Des RochersM I Saunders
Jan 1, 1980·Pharmacology & Therapeutics·C Wasternack
Aug 1, 1996·The Journal of Clinical Investigation·X WeiP Fernandez-Salguero
Sep 2, 1998·British Journal of Clinical Pharmacology·S A RidgeH L McLeod
Feb 23, 1999·British Journal of Cancer·G MilanoN Renée
Aug 10, 1999·Critical Reviews in Oncology/hematology·E Gamelin, M Boisdron-Celle
Feb 13, 2001·Acta Anaesthesiologica Scandinavica·T H Fagerlund, O Braaten
Mar 15, 2001·The New England Journal of Medicine·E A Eisenhauer
Jul 14, 2001·The New England Journal of Medicine·D J SargentR L Schilsky
Sep 18, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M L RothenbergS Wadler
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Mar 6, 2003·Biochimica Et Biophysica Acta·James W Watters, Howard L McLeod
Jan 8, 2004·British Journal of Cancer·S Marsh, H L McLeod
Jan 11, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J O EbbertP Yang
Apr 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Piyali DasguptaSrikumar Chellappan
May 29, 2008·European Journal of Clinical Pharmacology·Srikumar SahasranamanSandip Roy
Nov 28, 2008·International Journal of Radiation Oncology, Biology, Physics·André FortinEric Vigneault
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Jan 27, 2011·Fundamental & Clinical Pharmacology·D KrishnakumarC Adithan
Sep 3, 2011·Journal of Oncology Practice·Glen MorganLisa Sanderson Cox
Oct 1, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Munindra RuwaliDevendra Parmar
Oct 4, 2012·Pharmacotherapy·William P PetrosScott A Weed

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Oct 27, 2020·The Journal of Gene Medicine·Shaik Mohammad NaushadVijay Kumar Kutala

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