Association of Genetic Variants in NF-kB with Susceptibility to Breast Cancer: a Case Control Study

Pathology Oncology Research : POR
Rabeb M GhaliWassim Y Almawi

Abstract

Insofar as altered NF-κB signaling stemming from the presence of specific genetic variants in NF-κB gene contribute to cancer pathogenesis, this study evaluated the association between NF-κB rs147574894/I552V, rs148626207/M860T rs3774937 and rs1598859 variants and breast cancer and associated features and complications. This was a retrospective case-control study, which involved 207 women with breast cancer, and 214 cancer-free women who served as controls. NF-κB genotyping was done by real-time PCR. Significantly higher rs3774937 minor allele frequencies (MAF), and lower rs147574894 MAF were seen among breast cancer patients, thereby imparting disease susceptibility and protective nature to these variants, respectively. Significant association of rs3774937 and rs147574894 genotypes with breast cancer was seen under the dominant model. Histological type and grade, molecular type, Her2 positivity and ER+/Her2- correlated positively, while distant metastasis negatively correlated with rs3774937. On the other hand, rs147574894 negatively correlated with histological type and grade, tumor size, Her2 positivity, molecular type, and ER+/Her2-, while rs148626207 correlated positively with histological grade, but negatively with distan...Continue Reading

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Citations

Aug 14, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mariem Hadj-AhmedWassim Y Almawi

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Methods Mentioned

BETA
biopsy
genotyping
PCR
hormone replacement therapy

Software Mentioned

Genetic Power Calculator
Haploview
SPSS

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