Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population.

Diabetologia
C HuWeiping Jia

Abstract

Chromosome 1q21-q24 has been shown to be linked to type 2 diabetes. The International Type 2 Diabetes 1q Consortium showed that one of the nominal associations was located in the NOS1AP gene. Although this association was not replicated in additional samples of European descent, it remains unknown whether NOS1AP plays a role in Chinese individuals. In stage 1 analyses, 79 single nucleotide polymorphisms (SNPs) of the NOS1AP gene were successfully genotyped in a group of Shanghai Chinese individuals, comprising 1,691 type 2 diabetes patients and 1,720 control participants. In stage 2 analyses, the SNP showing the strongest association was genotyped in additional Chinese individuals, including 1,663 type 2 diabetes patients and 1,408 control participants. In stage 1 analyses, 20 SNPs were nominally associated with type 2 diabetes (p < 0.05), with SNP rs12742393 showing the strongest association (OR 1.24 [95% CI 1.11-1.38]; p = 0.0002, empirical p = 0.019). Haplotype analysis also confirmed the association between rs12742393 and type 2 diabetes. In stage 2 analyses, the difference in allele frequency distribution of rs12742393 did not reach statistical significance (p = 0.254). However, the meta-analysis showed a significant assoc...Continue Reading

References

Oct 14, 1998·The Journal of Clinical Investigation·R ShankarA D Baron
Sep 14, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·A L Gloyn, M I McCarthy
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Samie R JaffreySolomon H Snyder
Apr 23, 2003·The Journal of Cell Biology·Megan A Rizzo, David W Piston
Aug 28, 2003·Diabetes·Selim CellekSalvador Moncada
Mar 30, 2004·Diabetes·Carl D LangefeldUNKNOWN Insulin Resistance Atherosclerosis Study Family Study
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 25, 2004·Experimental Cell Research·Laurent SégalatJudy E Anderson
May 2, 2006·Nature Genetics·Dan E ArkingAravinda Chakravarti
Nov 11, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hong ZhengKaushik P Patel
Mar 6, 2007·Progress in Retinal and Eye Research·Noboru Toda, Megumi Nakanishi-Toda
Apr 19, 2007·The Journal of Clinical Endocrinology and Metabolism·Steven J R MeexTjerk W A de Bruin
Jun 19, 2007·Nature Genetics·Jonathan MarchiniPeter Donnelly
Jun 20, 2007·Circulation·Albert-Jan L H J AarnoudseBruno H C Stricker
Mar 4, 2009·The American Journal of Psychiatry·Naomi S WrattenLinda M Brzustowicz
Apr 25, 2009·Diabetes·Inga ProkopenkoUNKNOWN International Type 2 Diabetes 1q Consortium

❮ Previous
Next ❯

Citations

Oct 7, 2011·Journal of Diabetes Investigation·Weiping Jia
Jan 27, 2012·Journal of Human Genetics·Rubina TabassumDwaipayan Bharadwaj
Sep 29, 2012·Molecular Diagnosis & Therapy·Gaia Chiara Mannino, Giorgio Sesti
Dec 12, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·David J MargolisNandita Mitra
Aug 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·J LuW Jia
Jul 12, 2012·Journal of Diabetes·Weihui YuWeiping Jia
Aug 3, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·R ZhangW Jia
Jan 7, 2015·Pharmacogenomics·Miao ChenWeiping Jia
Nov 22, 2016·International Journal of Molecular Sciences·Shangfeng GaoRutong Yu
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yaodong ShenHong Liu
Oct 4, 2017·The Journal of Biological Chemistry·Stephen R ThomDavid J Margolis
Jul 30, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·David J MargolisStephen R Thom
Dec 6, 2018·Diabetes/metabolism Research and Reviews·Gaia Chiara ManninoGiorgio Sesti
Mar 26, 2019·Diabetes/metabolism Research and Reviews·Weiping JiaUNKNOWN Chinese Diabetes Society

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.