Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children

Cancer Causes & Control : CCC
Ling-I HsuPatricia Buffler

Abstract

Genome-wide association studies focusing on European-ancestry populations have identified ALL risk loci on IKZF1, ARID5B, and CEBPE. To capture the impacts of these genes on ALL risk in the California Hispanic population, we comprehensively assessed the variation within the genes and further assessed the joint effects between the genetic variation and surrogates for early-life infections (the presence of older siblings, daycare attendance, and ear infections). Genotypic data for 323 Hispanic ALL cases and 454 controls from the California Childhood Leukemia Study were generated using Illumina OmniExpress v1 platform. Logistic regression assuming a log-additive model estimated odds ratios (OR) associated with each SNP, adjusted for age, sex, and the first five principal components. In addition, we examined potential interactions between six ALL risk alleles and surrogates for early-life infections using logistic regression models that included an interaction term. Significant associations between genotypes at IKZF1, ARID5B, and CEBPE and ALL risk were identified: rs7780012, OR 0.50, 95% confidence interval (CI) 0.35-0.71 (p = 0.004); rs7089424, OR 2.12, 95% CI 1.70-2.65 (p = 1.16 × 10(-9)); rs4982731, OR 1.69, 95% CI 1.37-2.08 (p...Continue Reading

References

Jul 1, 1990·Statistics in Medicine·Y Hochberg, Y Benjamini
Jul 2, 1997·Journal of the National Cancer Institute·T WestergaardM Melbye
Feb 1, 2002·International Journal of Epidemiology·J D DockertyK J Bunch
May 3, 2002·British Journal of Cancer·X MaP Reynolds
May 9, 2002·Apoptosis : an International Journal on Programmed Cell Death·C SchmittA Rebollo
Sep 3, 2003·Nature Reviews. Cancer·Mel F Greaves, Joe Wiemels
Apr 9, 2004·The New England Journal of Medicine·Ching-Hon PuiJames R Downing
May 7, 2004·American Journal of Epidemiology·Xiaomei MaPeggy Reynolds
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xiaomei MaJohn K Wiencke
Feb 10, 2006·Nature Reviews. Cancer·Mel Greaves
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Melinda C AldrichPatricia A Buffler
Dec 22, 2006·American Journal of Epidemiology·E RomanUNKNOWN United Kingdom Childhood Cancer Study Investigators
Mar 21, 2007·Environmental Health Perspectives·Siobhán M O'Connor, Roumiana S Boneva
Sep 18, 2007·Nature Genetics·Barbara E StrangerEmmanouil T Dermitzakis
Nov 1, 2008·Bioinformatics·Andrew D JohnsonPaul I W de Bakker
Jan 9, 2009·The New England Journal of Medicine·Charles G MullighanUNKNOWN Children's Oncology Group
Aug 18, 2009·Nature Genetics·Lisa R TreviñoMary V Relling
Jan 30, 2010·International Journal of Epidemiology·Kevin Y UrayamaXiaomei Ma
Mar 13, 2010·Cancer Treatment Reviews·Tim Eden
Mar 17, 2010·Cancer Treatment Reviews·Peter Kaatsch
Sep 3, 2010·American Journal of Epidemiology·Jérémie RudantJacqueline Clavel
Oct 5, 2010·International Journal of Epidemiology·Karen BartleyPatricia Buffler
Oct 6, 2010·The Pharmacogenomics Journal·T M Baye, R A Wilke
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kajsa PaulssonBertil Johansson
Feb 1, 2011·International Journal of Cancer. Journal International Du Cancer·Kevin Y UrayamaPatricia A Buffler
Apr 12, 2011·Molecular Immunology·Liza B John, Alister C Ward
Dec 15, 2012·International Journal of Hematology·Kevin Y UrayamaShuki Mizutani
Jul 10, 2013·Cancer Causes & Control : CCC·Anand P ChokkalingamPatricia A Buffler

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Citations

Nov 10, 2015·Journal of the National Cancer Institute·Frank L MeyskensDavid S Alberts
Aug 3, 2017·Genetic Testing and Molecular Biomarkers·Boshra Al-AbsiSekaran Muniandy
Feb 28, 2019·Genetic Testing and Molecular Biomarkers·Amrita BhatRakesh Kumar
May 22, 2019·International Journal of Hematology·Ju-Le YangHong Wang
Feb 23, 2020·International Journal of Molecular Sciences·Pavan Kumar DhanyamrajuYali Ding
Apr 7, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Boshra Al-AbsiSekaran Muniandy
Sep 15, 2017·Medical Oncology·Angela Gutierrez-CaminoAfrica García-Orad
Jun 23, 2019·Annals of Hematology·Adriana Reyes-LeónPatricia Pérez-Vera
Mar 5, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ling-I HsuLisa F Barcellos
Oct 2, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heng XuJun J Yang

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