Association of gestational diabetes mellitus and abnormal vaginal flora with adverse pregnancy outcomes

Medicine
Xinhong ZhangDan Li

Abstract

Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes. This study aimed to examine the association between GDM and abnormal vaginal flora, and the association between abnormal vaginal flora and adverse pregnancy outcomes.This was a prospective study of pregnant women who visited Xuanwu Hospital of the Capital Medical University (Beijing, China) between February and October 2015. All women were screened for GDM according to the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) recommendations. Vaginal secretions were sampled at 28 to 30 and 37 to 40 weeks. Microorganisms were examined.The women were 28.3 ± 2.6 years and their body mass index was 22.8 ± 1.4 kg/m. GDM was associated with higher frequencies of vulvovaginal candidiasis (22.6% vs 9.7%, P < .001), premature rupture of membranes (PROM) (22.6% vs 11.5%, P = .004), premature delivery (16.1% vs 5.5%, P = .02), chorioamnionitis/puerperal infection (19.4% vs 4.5%, P < .001), macrosomia (9.7% vs 4.0%, P = .04), neonatal hypoglycemia (5.4% vs 1.0%, P = .02), and neonatal referral (15.1% vs 6.5%, P = .008). Among healthy women, abnormal flora was associated with PROM (19.4% vs 7.5%, P = .02) and chorioamnionitis/puerperal...Continue Reading

References

Sep 1, 1993·Sexually Transmitted Diseases·A A HoosenM A Omar
Sep 10, 1998·American Journal of Obstetrics and Gynecology·T S NesbittB Herrchen
May 12, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J GuggenheimerT Orchard
Aug 1, 2002·Journal of Clinical Microbiology·Alejandra VásquezGöran Molin
Jul 16, 2003·American Journal of Obstetrics and Gynecology·Harald LeitichPeter Husslein
Dec 4, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A S IbaraA M Le Flohic
Mar 5, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Dorota NowakowskaJan Wilczynski
Aug 9, 2005·Clinics in Perinatology·Robert L GoldenbergDerek C Johnson
Jan 9, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·R RomeroM Mazor
Jun 15, 2007·Lancet·Jack D Sobel
Jun 19, 2007·Obstetrics and Gynecology Clinics of North America·J Seth Hawkins, Brian M Casey
Jul 27, 2007·Journal of Clinical Microbiology·Tell Jakobsson, Urban Forsum
Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
Jan 23, 2010·Obstetrics and Gynecology·Joseph R BiggioDwight J Rouse
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jan 22, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·R F LamontR Romero
Sep 10, 2011·Bioinformatics·Tanja Magoč, Steven L Salzberg
Sep 21, 2011·Pediatrics·Yoram BentalUNKNOWN Collaboration With the Israel Neonatal Network
Jul 31, 2012·Journal of Diabetes and Its Complications·Ishan HirjiAndres Gomez-Caminero
Apr 27, 2013·BMC Infectious Diseases·Marcos Daniel Martínez-PeñaMa Guadalupe Aguilera-Arreola
Oct 31, 2013·Archives of Gynecology and Obstetrics·Sandra BorgesPaula Teixeira
Mar 12, 2015·Scientific Reports·David A MacIntyrePhillip R Bennett
Dec 23, 2015·Critical Reviews in Microbiology·Bruna GonçalvesSónia Silva
Jan 13, 2017·Obstetrics and Gynecology·Michael W VarnerUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU)
Dec 10, 2017·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Feb 3, 2021·Mycoses·Alex FarrWerner Mendling
Mar 9, 2021·Taiwanese Journal of Obstetrics & Gynecology·Dominika Pykało-GawińskaEwa Romejko-Wolniewicz
Jul 25, 2021·International Journal of Environmental Research and Public Health·Elia Shazniza ShaayaYin Ping Wong
Sep 26, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Dalia RafatShamsi Khalid

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Methods Mentioned

BETA
contraception
cesarean section

Software Mentioned

USEARCH
QIIME
Fast Length Adjustment of Short reads
SPSS

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