Association of Glycated Hemoglobin Levels With Risk of Pancreatic Cancer

JAMA Network Open
Bechien U WuWansu Chen

Abstract

New-onset diabetes after the age of 50 years is a potential indicator of pancreatic cancer. Understanding the associations between hyperglycemia, diabetes, and pancreatic cancer, including pancreatic ductal adenocarcinoma, is key to developing an approach to early detection. To assess the association of elevation in glycated hemoglobin (HbA1c) with the risk of pancreatic cancer. This cohort study was conducted using data collected from an integrated health care system in California. A total of 851 402 patients aged 50 to 84 years who had HbA1c measurements taken between 2010 and 2014 were identified as the base cohort, with 12 contemporaneous cohorts created based on varying HbA1c thresholds (ie, 6.1%, 6.3%, 6.5%, and 6.7%) and prior diabetes status. Data analysis was conducted from August 2018 to September 2019. New cases of pancreatic cancer identified through cancer registry and California death files during a 3-year period. Three-year risk, incidence rate, sensitivity, number of patients needed to screen to detect 1 case, timing, and stage at diagnosis were determined. Among 851 402 patients in the base cohort, 447 502 (52.5%) were women, 255 441 (30.0%) were Hispanic participants, 383 685 (45.1%) were non-Hispanic white pa...Continue Reading

References

Aug 9, 2005·Gastroenterology·Suresh T ChariGloria M Petersen
May 10, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marcia Irene CantoAnthony N Kalloo
Dec 30, 2008·The Lancet Oncology·Rahul PannalaSuresh T Chari
Mar 26, 2009·Journal of the National Cancer Institute·Nadia HowladerBrenda K Edwards
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
May 20, 2015·Gut·F HarinckUNKNOWN Dutch research group on pancreatic cancer surveillance in high-risk individuals
Apr 27, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans VasenDetlef K Bartsch
May 17, 2017·Diabetes·Dana K AndersenJames L Abbruzzese
May 19, 2018·Gastroenterology·Ayush SharmaSuresh T Chari
Jun 20, 2018·Journal of the National Cancer Institute·Veronica Wendy SetiawanKristine R Monroe
Oct 17, 2018·Pancreas·Anirban MaitraUNKNOWN Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Feb 6, 2019·Gastroenterology·Aatur D SinghiAnirban Maitra
Jun 17, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anna TavakkoliCaitlin C Murphy
Aug 7, 2019·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceJohn B Wong
Nov 7, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Nina N SanfordDavid J Sher

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Citations

Nov 4, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christie Y JeonJoseph R Pisegna

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