Association of graft neutrophil sequestration with delayed graft function in clinical renal transplantation

Transplantation
Arto J TurunenEero J Pesonen

Abstract

The authors studied the impact of neutrophil activation, detected in experimental models, on reperfusion injury in clinical renal transplantation. Forty-five patients from a larger trial comparing three immunosuppressive protocols were recruited: perioperative antithymocyte globulin (ATG) with low initial cyclosporine A (CsA) triple therapy (group A, n=15); two-dose basiliximab with low initial CsA triple therapy (group B, n=16); and conventional triple therapy (group C, n=14). Blood samples were obtained preoperatively, before reperfusion, and at 1 and 5 min after reperfusion. During reperfusion, samples were collected from the iliac artery and the graft vein for calculation of transrenal differences (Delta) of study parameters. Leukocyte differential counts, plasma lactoferrin concentration, and neutrophil CD11b and L-selectin expressions were assessed. Graft blood flow was measured at 2 and 30 min after reperfusion. ATG induced neutrophil activation already before reperfusion. Thus, group A was excluded, but groups B and C were pooled for analysis of reperfusion-induced neutrophil activation. At 1 min after reperfusion, lactoferrin concentration was higher in graft vein than iliac artery, yielding Delta=15 microg/L (P<0.05)....Continue Reading

References

Aug 2, 1990·Nature·T A Springer
May 12, 1995·The Journal of Biological Chemistry·R P McEverR D Cummings
Sep 15, 1993·Journal of Immunological Methods·H RepoM Leirisalo-Repo
Dec 31, 1997·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·F Dallegri, L Ottonello
Jun 3, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·L E KyllönenJ Ahonen
Jan 5, 2002·Atherosclerosis·William S ShinStanley G Rockson

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Citations

Dec 2, 2006·The Journal of Antibiotics·Hideaki UiSatoshi Omura
Oct 30, 2010·Nature Reviews. Drug Discovery·Volker BrinkmannPascale Burtin
Jan 26, 2008·American Journal of Nephrology·Björn JüttnerDirk Scheinichen
Dec 17, 2009·Current Opinion in Organ Transplantation·Maarten G J SnoeijsWim A Buurman
Feb 19, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Malgorzata Zynek-LitwinMarian Klinger
Mar 29, 2014·The Journal of Surgical Research·Min-Wen SuChen-Fuh Lam
Dec 29, 2015·Transplantation Proceedings·A J TurunenE Pesonen
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Arto J TurunenEero J Pesonen
Jul 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James D Perkins
Mar 9, 2011·European Journal of Clinical Investigation·Frank UlrichJohann Pratschke
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Angela C WebsterJonathan C Craig

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