Association of GTF2I gene polymorphisms with renal involvement of systemic lupus erythematosus in a Chinese population

Medicine
Yanming MengYongkang Wu

Abstract

The purposes of the study was to validate the relationship between General transcription factor II-I (GTF2I) genetic variants and kidney involvements of systemic lupus erythematosus (SLE) patients in a Chinese Han population.Samples from 400 SLE patients and 400 age- and sex-matched healthy controls were collected and genotyped by improved multiplex ligation detection reaction technique. The relationship between gene polymorphism of rs117026326, rs73366469, and susceptibility, progression of SLE were analyzed.The present study provided evidence that rs117026326 and rs73366469 were both associated with SLE susceptibility (both C vs T: P < .001). The analysis of dominant, recessive disease model provided us with further validation (P < .001). Both gene polymorphisms are associated with a triad of disease manifestations among SLE patients. Patients carrying genotype TT of rs117026326 had lower 24-hour urinary total protein (24 hours UTP, g/24 hours), 24-hour urinary protein level (g/L·24 hours), lower frequency of the proteinuria and lupus nephritis (LN). Patients carrying genotype TT at rs73366469 had higher 24-hour urinary protein level, higher frequency of the proteinuria, LN and positive anti-dsDNA than those with other genoty...Continue Reading

References

Aug 10, 2013·Journal of the American Society of Nephrology : JASN·Maciej Lech, Hans-Joachim Anders
Jan 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brad H Rovin, Samir V Parikh
Nov 11, 2014·Annals of Internal Medicine·Zhihong LiuMinlin Zhou
Mar 12, 2016·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Rawhya R El-ShereefHeba Tawfik
Oct 26, 2016·Journal of Autoimmunity·Hai LongQianjin Lu
Apr 10, 2018·Reviews on Recent Clinical Trials·Sabahat SarfarazRana Muzaffar
Jun 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sonya J WolfJ Michelle Kahlenberg
Jun 30, 2018·Zeitschrift für Rheumatologie·S MelderisO M Steinmetz

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Citations

Sep 11, 2020·Journal of Clinical Pathology·Shrinidhi NathanyAnurag Mehta
Feb 10, 2021·Virchows Archiv : an International Journal of Pathology·Mélanie LegrandGonzague de Pinieux

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Methods Mentioned

BETA
genotyping

Software Mentioned

Haploview
Power and Size Calculation
iMLDR
Statistical Package for the Social Sciences ( SPSS )

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