PMID: 6104515Jun 19, 1980Paper

Association of guanylate cyclase with the axoneme of retinal rods

Biochimica Et Biophysica Acta
D FleischmanR G Pannbacker

Abstract

Axonemes were isolated from purified bovine retinal rod outer segments by dissolving the outer segment membranes in detergent and separating the axonemes by centrifugation on a linear detergent-containing sucrose density gradient. Guanylate cyclase (GTP pyrophosphate-lyase (cyclizing), EC 4.61.2) activity was concentrated in the axoneme fraction. Guanylate cyclase eluted in the void volume when detergent-solubilized rod outer segments were subjected to exclusion chromatography on Sepharose 4B. Attempts to extract guanylate cyclase from isolated axonemes with salt, EDTA, base and other reagents were successful.

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Citations

Jun 1, 1994·Amino Acids·R K SharmaA Sitaramayya
Mar 1, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·U SchraermeyerK Heimann
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