Association of haemolytic uraemic syndrome with dysregulation of chemokine receptor expression in circulating monocytes

Clinical Science
Maria Victoria RamosM S Palermo

Abstract

Haemolytic uraemic syndrome (HUS) is the major complication of Escherichia coli gastrointestinal infections that are Shiga toxin (Stx) producing. Monocytes contribute to HUS evolution by producing cytokines that sensitize endothelial cells to Stx action and migration to the injured kidney. As CC chemokine receptors (CCRs) are involved in monocyte recruitment to injured tissue, we analysed the contribution of these receptors to the pathogenesis of HUS. We analysed CCR1, CCR2 and CCR5 expression in peripheral monocytes from HUS patients during the acute period, with healthy children as controls. We observed an increased expression of CCRs per cell in monocytes from HUS patients, accompanied by an increase in the absolute number of monocytes CCR1+, CCR2+ and CCR5+. It is interesting that prospective analysis confirmed that CCR1 expression positively correlated with HUS severity. The evaluation of chemokine levels in plasma showed that regulated on activation of normal T-cell-expressed and -secreted (RANTES) protein was reduced in plasma from patients with severe HUS, and this decrease correlated with thrombocytopenia. Finally, the expression of the higher CCRs was accompanied by a loss of functionality which could be due to a mech...Continue Reading

References

Jan 1, 1973·Nephron·C A GianantonioE T Sojo
Jan 1, 1981·Journal of Immunological Methods·J A Hardin, J T Downs
Jul 1, 1995·Kidney International·G Remuzzi, P Ruggenenti
Jan 24, 1998·The Journal of Biological Chemistry·R J NibbsG J Graham
Jul 17, 1998·Clinical Microbiology Reviews·J C Paton, A W Paton
Oct 10, 1998·Kidney International·A K HughesD E Kohan
Dec 22, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C LitalienE Seidman
Jan 6, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F ProulxE Seidman
May 16, 2000·Journal of Leukocyte Biology·C WeberH W Ziegler-Heitbrock
Sep 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C MasriJ Carcillo
Jun 14, 2002·Alcohol·Hartmut Jaeschke
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna M FraAlberto Mantovani
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulrich A MausJürgen Lohmeyer
Mar 13, 2003·Kidney International·Hans-Joachim AndersDetlef Schlöndorff
Apr 23, 2004·Trends in Immunology·Bernhard MoserPius Loetscher
Sep 11, 2004·Biochemical and Biophysical Research Communications·Lucy GardnerJim Middleton
Jul 28, 2005·Journal of Leukocyte Biology·Gabriela C FernándezMarina S Palermo
Aug 31, 2006·The Journal of Infectious Diseases·Chandy C JohnMichael J Boivin
Dec 1, 2006·Journal of Leukocyte Biology·Loems Ziegler-Heitbrock
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristina ZanchiJacek Hawiger
Jan 22, 2009·PloS One·Lisa F P NgYee-Sin Leo
Dec 10, 2009·Science Signaling·Alma ZerneckeChristian Weber
Feb 26, 2010·Current Vascular Pharmacology·Sara GiuntiGabriella Gruden
Dec 29, 2011·The American Journal of Pathology·Maria V RamosMarina Palermo
Apr 6, 2013·Immunology Letters·Laura J ApplebyFrancisca Mutapi

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Citations

Feb 16, 2018·European Journal of Immunology·Judith-Mira PohlDaniel R Engel
Jan 27, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ramon Alfonso ExeniMarina Sandra Palermo
Apr 12, 2019·Toxins·Moo-Seung Lee, Vernon L Tesh
Mar 6, 2021·Journal of Clinical Immunology·Bert Malengier-DevliesCarine Wouters

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