Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus

Journal of Diabetes Research
Caroline Pereira DominguetiAna Paula Fernandes

Abstract

This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (albuminuria ≥ 30 mg/g and/or GFR < 60 mL/min/1.73 m(2)), n = 65; and without nephropathy (albuminuria < 30 mg/g and GFR ≥ 60 mL/min/1.73 m(2)), n = 60. INF-γ, IL-6, IL-10, and TNF-α plasma levels were determined by flow cytometry. VWF, ADAMTS13 antigen, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay and ADAMTS13 activity was assessed by fluorescence resonance energy transfer assay. Elevated levels of INF-γ, VWF, ADAMTS13 antigen, D-Dimer, and reduced ADAMTS13 activity/antigen ratio were observed in patients with nephropathy as compared to those without nephropathy (P = 0.001, P < 0.001, P < 0.001, P < 0.001, and P < 0.001, resp.). Cytokines and haemostatic biomarkers remained associated with nephropathy after adjustments (use of statin, acetylsalicylic acid, angiotensin converting enzyme inhibitor, and angiotensin antagonist). INF-γ, TNF-α, and IL-10 significantly correlated with haemostatic biomarkers. Inflammatory and hypercoagulability status are associ...Continue Reading

References

Aug 1, 1991·Diabetes·C D StehouwerG J Den Ottolander
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Pawel P WolkowAndrzej S Krolewski
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 29, 2009·Pakistan Journal of Biological Sciences : PJBS·Reza NosratabadiH Hakimi
Feb 9, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chia-Chao WuYuh-Feng Lin
Mar 25, 2010·European Journal of Endocrinology·Karine SahakyanRonald Klein
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Sho-Ichi Yamagishi, Takanori Matsui
Oct 28, 2010·Biochemical and Biophysical Research Communications·Keiichiro MatobaKazunori Utsunomiya
Mar 25, 2011·Diabetes/metabolism Research and Reviews·Cosimo GianniniC J H Kelnar
May 4, 2011·Nature Reviews. Nephrology·Juan F Navarro-GonzálezJavier García-Pérez
Sep 15, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·M E HellemonsM Rudnicki
Jan 24, 2012·Journal of the American Society of Nephrology : JASN·Monika A NiewczasAndrzej S Krolewski
Nov 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Caroline Pereira DominguetiAna Paula Fernandes
Feb 8, 2013·Frontiers in Endocrinology·Keizo KanasakiDaisuke Koya
Jul 3, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Riyaz MohamedGanesan Ramesh
Aug 29, 2013·Science Signaling·Parameswaran RamakrishnanDavid Baltimore
Jun 18, 2014·World Journal of Diabetes·Montserrat B Duran-Salgado, Alberto F Rubio-Guerra
Dec 30, 2014·Diabetes Care
Feb 13, 2015·Biochemia Medica·Jasenka TrifunovićVesna Horvat

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Citations

Jan 24, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Vibeke BratsethIngebjørg Seljeflot
Dec 30, 2020·Klinicheskaia laboratornaia diagnostika·M V PresnyakovaN N Karyakin

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Methods Mentioned

BETA
FACS
enzyme-linked immunosorbent assay
fluorescence resonance

Software Mentioned

SPSS
BD CBA

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