Association of haptoglobin phenotypes with markers of diabetic nephropathy in Type 2 diabetes mellitus

Journal of Diabetes and Its Complications
Samir M AwadallahHisham Hilow

Abstract

Recent studies have suggested an inheritable influence of haptoglobin phenotypes on the development of microalbuminuria in diabetic patients. In this study, we aimed to investigate whether microalbuminuria and serum levels of Cystatin C (Cys C) were correlated with haptoglobin phenotypes in patients with Type 2 diabetes mellitus. Fasting blood samples and first morning urine specimens were collected from 216 patients with type 2 diabetes (mean age 60.8+/-6.8) and from 108 healthy controls (mean age 59.3+/-6.5 years). Serum was used for the determination of Cys C, creatinine, and haptoglobin (Hp) phenotypes, while urine specimens were used for the determination of microalbuminuria. Microalbuminuria was expressed as albumin (mg)/creatinine (g) ratio [ACR (mg/g)], and patients were divided into three groups according to the values of ACR: normoalbuminuria (<30), microalbuminuria (30-300) and macroalbuminuria (>300). Irrespective of Hp phenotypes, Cys C, but not creatinine, was significantly higher in patients than that in controls. According to haptoglobin phenotypes, however, the levels of Cys C, duration of diabetes, and age, were significantly higher in patients with Hp1-1 phenotype than that in patients with the other phenotyp...Continue Reading

References

Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E CollA Darnell
Aug 26, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Hamad, S Awadallah
Jan 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D Fliser, E Ritz
May 31, 2001·Diabetologia·F M NakhoulA P Levy
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vikas R DharnidharkaGary Stevens
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Garabed EknoyanRobert Toto
Jul 27, 2004·Proteomics·Chi Feng TsengSimon J T Mao
Oct 27, 2004·Diabetes Care·Elise WasénKerttu Irjala
Feb 27, 2007·Vascular Health and Risk Management·Rabea Asleh, Andrew P Levy

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Citations

May 21, 2009·Annals of Human Biology·Vânia P A WobetoMaria de Fátima Sonati
May 1, 2009·Diabetes/metabolism Research and Reviews
May 26, 2018·European Journal of Preventive Cardiology·Rinkoo Dalan, Goh Liuh Ling

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