Association of heart rate and outcomes in a broad spectrum of patients with chronic heart failure: results from the CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and morbidity) program

Journal of the American College of Cardiology
Davide CastagnoCHARM Investigators

Abstract

The aim of this study was to explore the relationship between baseline resting heart rate and outcomes in patients with chronic heart failure (HF) according to baseline left ventricular ejection fraction (LVEF) and cardiac rhythm. Elevated resting heart rate is associated with worse outcomes in patients with HF and reduced LVEF. Whether this association is also found in patients with HF and preserved LVEF is uncertain, as is the predictive value of heart rate in patients in atrial fibrillation (AF). Patients enrolled in the CHARM (Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity) Program were divided into groups by tertiles of baseline heart rate. Cox proportional hazard models were used to investigate the association between heart rate and pre-specified outcomes in the overall population as well as in subgroups defined according to LVEF (≤ 40% vs. >40%) and presence (or absence) of AF at baseline. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worse outcomes when compared with those in the lowest heart rate group (e.g., for the composite of cardiovascular death or HF hospital stay hazard ratio: 1.23, 95% confidence interval: 1.11 to 1.36, p < 0.0...Continue Reading

References

May 1, 1992·Circulation·L A MulieriN R Alpert
Mar 1, 1988·Journal of the American College of Cardiology·J E AtwoodV Froelicher
Jan 1, 1985·Statistics in Medicine·J Cuzick
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Aug 26, 1998·Circulation·K NarkiewiczV K Somers
Apr 3, 2003·The American Journal of Cardiology·William H Maisel, Lynne Warner Stevenson
Sep 19, 2003·Lancet·Marc A PfefferUNKNOWN CHARM Investigators and Committees
Aug 28, 2007·Journal of the American College of Cardiology·Kim FoxUNKNOWN Heart Rate Working Group
Nov 23, 2007·The New England Journal of Medicine·Rui WangJeffrey M Drazen
Dec 20, 2008·International Journal of Cardiology·Emil Loldrup FosbølUNKNOWN Danish Investigations and Arrhythmia ON Dofetilide Study Group
Nov 11, 2009·Circulation·Mastaneh Ahmadi-KashaniUNKNOWN INTRINSIC RV Study Investigators
Jan 28, 2010·Diabetes Care·Rodica Pop-Busui
Jun 29, 2010·International Journal of Cardiology·Vicente Bertomeu-GonzálezAngel Llàcer
Oct 12, 2010·Journal of Cardiac Failure·John R Kapoor, Paul A Heidenreich

❮ Previous
Next ❯

Citations

Nov 28, 2012·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Prakash C Deedwania
Jan 7, 2014·Internal Medicine·Koichiro ImaiKiyoshi Yoshida
Jan 31, 2014·Current Heart Failure Reports·Marwan F Jumean, Michael S Kiernan
Mar 8, 2013·Future Cardiology·Rashmi U Hottigoudar, Rakesh Gopinathannair
May 22, 2013·Heart Failure Reviews·Rafik TadrosDenis Roy
Oct 9, 2013·Arquivos brasileiros de cardiologia·Irineu Blanco MorenoAntônio Carlos Pereira-Barretto
Sep 14, 2012·Heart Failure Reviews·Maya Guglin
Oct 22, 2014·Scandinavian Cardiovascular Journal : SCJ·Oleg E Osadchii
Sep 24, 2015·The Canadian Journal of Cardiology·Jonathan G HowlettUNKNOWN Canadian Cardiovascular Society Heart Failure Guidelines Panels
Nov 7, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Olaf OldenburgDieter Horstkotte
Nov 25, 2014·European Heart Journal·Michel Komajda
Jun 23, 2015·The Canadian Journal of Cardiology·G B John ManciniJean-Claude Tardif
Mar 14, 2014·JACC. Heart Failure·Michiel RienstraDirk J Van Veldhuisen
May 1, 2015·BMC Pulmonary Medicine·Helge HaarmannStefan Andreas
Feb 18, 2016·European Journal of Preventive Cardiology·Yuko KatoTakeshi Yamashita
May 10, 2017·European Journal of Preventive Cardiology·Wesley T O'NealElsayed Z Soliman
Jan 28, 2015·Lancet·John J V McMurray, Dirk J van Veldhuisen
Feb 13, 2018·Heart Failure Reviews·Jasneet DevgunWaqas Ghumman
May 28, 2014·European Journal of Heart Failure·Michael BöhmUNKNOWN I-Preserve Committees and Investigators
Apr 6, 2018·The Journal of Cardiovascular Nursing·Marilyn A Prasun, Nancy M Albert
Aug 18, 2018·Expert Opinion on Drug Safety·Gabriela AndriesWilbert S Aronow
Sep 25, 2018·International Journal of Clinical Practice·Marcos GuzmanFrancisco Gomez
Apr 24, 2015·Journal of the American Heart Association·Warren K LaskeyUNKNOWN AHA Get With The Guidelines®‐Heart Failure Program
Oct 23, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jennifer C CookJo E Rodgers
Aug 10, 2013·Clinical Cardiology·Luis SargentoRoberto Palma dos Reis
Oct 19, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Shijun Li, Xiaoying Li
Jan 17, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Roy BeinartEyal Nof
Dec 17, 2016·Current Opinion in Cardiology·Robert J H Miller, Jonathan G Howlett
Sep 12, 2015·European Journal of Heart Failure·Joanne SimpsonUNKNOWN Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC)
Apr 25, 2018·Heart Failure Reviews·Dario GrandeNadia Aspromonte
Jan 11, 2020·Endocrinology, Diabetes & Metabolism·Bindu ChamarthiAnthony H Cincotta
Jun 14, 2013·European Journal of Heart Failure·Bart A MulderUNKNOWN RACE II investigators
Feb 6, 2017·Pacing and Clinical Electrophysiology : PACE·Bruce L WilkoffBrian Olshansky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.