Association of Helicobacter pylori infection with chronic obstructive pulmonary disease and chronic bronchitis: a meta-analysis of 16 studies

Infectious Diseases
Feng WangPing Lei

Abstract

Chronic obstructive pulmonary disease (COPD) and chronic bronchitis (CB) are common respiratory diseases globally. The aim of this meta-analysis was to quantify the risk of these two diseases being associated with Helicobacter pylori infection. A literature search was performed to identify studies published before 5 June 2014 for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for COPD and CB. Sixteen observational studies involving 1390 patients with COPD, 734 with CB and more than 13 000 controls were included. Helicobacter pylori infection was associated with an increased risk of COPD and CB [odds ratio (OR) 2.07, 95% confidence interval (CI) 1.81-2.36, p for heterogeneity = 0.05; and OR 1.57, 95% CI 1.33-1.86, p for heterogeneity = 0.08]. We discovered a significant association between CagA-positive strains and risk for COPD (OR 3.46, 95% CI 2.29-5.25, p for heterogeneity = 0.20). Our meta-analysis suggested a potential relationship between H. pylori infection and the development of COPD and CB.

References

Sep 16, 1995·BMJ : British Medical Journal·M Egger, G D Smith
May 1, 1994·British Heart Journal·M A MendallT C Northfield
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 28, 1999·Scandinavian Journal of Gastroenterology·M CaselliA Papi
Apr 14, 2000·Journal of Gastroenterology and Hepatology·A OgiharaH Mizukoshi
Aug 25, 2000·European Journal of Gastroenterology & Hepatology·G Parasher, G L Eastwood
Feb 24, 2001·Gastroenterology Clinics of North America·H Cohen
Feb 24, 2001·Epidemiologic Reviews·L M Brown
Feb 21, 2002·World Journal of Gastroenterology : WJG·F B XueD M Fan
Jun 8, 2002·Journal of Gastroenterology·Anastasios RoussosNikiforos Philippou
Oct 24, 2002·The European Respiratory Journal. Supplement·K F Chung
Jan 1, 2003·World Journal of Gastroenterology : WJG·Anastasios RoussosKonstantinos I Gourgoulianis
Feb 5, 2004·The Annals of Thoracic Surgery·Thanos AthanasiouBrian Glenville
Mar 1, 2005·Respiratory Medicine·Anastasios RoussosKonstantinos Gourgoulianis
Sep 6, 2005·Respiratory Medicine·Mehmet KanbayUgur Yilmaz
Dec 22, 2005·Respiration; International Review of Thoracic Diseases·Mehmet GencerNurten Aksoy
Jan 13, 2006·Gastroenterology·Marion RowlandBrendan Drumm
Mar 28, 2006·The Tohoku Journal of Experimental Medicine·Zhao Jian JunMasatomo Mori
May 19, 2006·The European Respiratory Journal·S SørhaugS Steinshamn
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Dec 26, 2008·International Journal of Epidemiology·Donna FullertonAndrew W Fogarty
Jan 27, 2012·Diabetes Care·Christie Y JeonAllison E Aiello
Feb 27, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Roshan SivaIan D Pavord
Dec 1, 2012·The Eurasian Journal of Medicine·Ali TabaruAli Sahin

❮ Previous
Next ❯

Citations

Nov 1, 2016·Nature Reviews. Microbiology·Kurtis F BuddenPhilip M Hansbro
Jun 1, 2017·Respiratory Research·Seung Won RaUNKNOWN Canadian Respiratory Research Network
Feb 19, 2020·Molecular Genetics & Genomic Medicine·Abolfazl Zendehdel, Maryam Roham
Oct 13, 2020·Frontiers in Immunology·April L RafteryMargaret L Hibbs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.