Association of hepatitis C virus infection with risk of ESRD: a population-based study

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Fu-Hsiung SuChih-Ching Yeh

Abstract

The association between chronic hepatitis C virus (HCV) infection and end-stage renal disease (ESRD) has been widely debated. National population-based cohort study. Insurance claims data from the Taiwan National Health Insurance Research Database in 2000-2005. Chronic HCV infection as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. ESRD as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. We identified 6,291 adults with chronic HCV infection. The control group included 31,455 sex- and age-matched individuals without evidence of chronic hepatitis. The incidence of ESRD was 2.14-fold higher in patients with chronic HCV infection (HR, 1.53; 95% CI, 1.17-2.01; P = 0.002) than in patients without HCV infection. Age stratification analysis showed that patients aged 50-59 years with chronic HCV infection (HR, 7.77; 95% CI, 4.23-14.3; P < 0.001) had the highest risk of developing ESRD relative to patients aged 20-49 years without chronic HCV infection (interaction P < 0.001). Lack of clinical data. Patients with chronic HCV infection are at greater risk of developing ESRD than individuals without chronic HCV infection. In addition, the risk o...Continue Reading

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