Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial.

JAMA Pediatrics
Pia Elisabeth NørrisgaardHans Bisgaard

Abstract

Enamel defects of developmental origin affect up to 38% of schoolchildren and is recognized as a global public health challenge. The impaired enamel formation results in pain owing to hypersensitivity, posteruptive breakdowns, rapid caries progression, and extractions in some cases. The etiology is unknown; therefore, prevention is currently not possible. To assess the association of a high-dose vitamin D supplementation in pregnant women with enamel defects and caries in their offspring. Post hoc analysis of a double-blind, single-center, randomized clinical trial, the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (COPSAC2010). Enrollment began March 2009 and included 623 women recruited at 24 weeks of pregnancy and 588 of their children. A dental examination was completed at age 6 years in 496 of 588 children (84%). Data were analyzed in 2018. High-dose vitamin D3 (2400 IU/d; N = 315) or matching placebo tablets (N = 308) from pregnancy week 24 to 1 week post partum. In addition, all women received 400 IU/d of vitamin D3 as part of standard care. Enamel defect was defined as having at least 1 molar affected by demarcated opacity, enamel breakdown, and/or atypical restoration. Caries was defined as decayed,...Continue Reading

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Citations

Jan 28, 2020·JAMA Pediatrics·Pia Elisabeth NørrisgaardHans Bisgaard
Jan 28, 2020·JAMA Pediatrics·Xiangling Deng, Wenquan Niu
Apr 16, 2020·International Journal of Paediatric Dentistry·Pia WogeliusDorte Haubek
May 18, 2020·International Journal of Paediatric Dentistry·Srinivasan Raj Samuel
Jun 4, 2020·Current Opinion in Obstetrics & Gynecology·Faustino R Pérez-LópezPeter Chedraui
Jan 17, 2020·Journal of Paediatrics and Child Health
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Jun 22, 2021·The Japanese Dental Science Review·Masato Saitoh, Seikou Shintani
Aug 21, 2021·Clinical Oral Investigations·Laura Jordana Santos LimaMaria Eliza Consolação Soares
Aug 26, 2021·International Journal of Paediatric Dentistry·Charlotte McCarraRona Leith

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