Association of Hippocampal Atrophy With Duration of Untreated Psychosis and Molecular Biomarkers During Initial Antipsychotic Treatment of First-Episode Psychosis

JAMA Psychiatry
Donald C GoffJijun Wang

Abstract

Duration of untreated psychosis (DUP) has been associated with poor outcomes in schizophrenia, but the mechanism responsible for this association is not known. To determine whether hippocampal volume loss occurs during the initial 8 weeks of antipsychotic treatment and whether it is associated with DUP, and to examine molecular biomarkers in association with hippocampal volume loss and DUP. A naturalistic longitudinal study with matched healthy controls was conducted at Shanghai Mental Health Center. Between March 5, 2013, and October 8, 2014, 71 medication-naive individuals with nonaffective first-episode psychosis (FEP) and 73 age- and sex-matched healthy controls were recruited. After approximately 8 weeks, 31 participants with FEP and 32 controls were reassessed. The participants with FEP were treated according to standard clinical practice with second-generation antipsychotics. Hippocampal volumetric integrity (HVI) (an automated estimate of the parenchymal fraction in a standardized hippocampal volume of interest), DUP, 13 peripheral molecular biomarkers, and 14 single-nucleotide polymorphisms from 12 candidate genes were determined. The full sample consisted of 71 individuals with FEP (39 women and 32 men; mean [SD] age,...Continue Reading

Citations

Nov 7, 2019·Journal of Clinical Psychopharmacology·Jie Yin YeeJimmy Lee
Mar 5, 2020·The American Journal of Psychiatry·Donald C GoffLorna Thorpe
Feb 13, 2020·The American Journal of Psychiatry·Katherine G JonasRoman Kotov
Jan 19, 2019·AJNR. American Journal of Neuroradiology·B A ArdekaniA H Bachman
Sep 3, 2020·Translational Psychiatry·Maureen McHugoStephan Heckers
Dec 15, 2018·Early Intervention in Psychiatry·Marcela Horvitz-LennonSoeren Mattke
Mar 15, 2020·Schizophrenia Research·Michelle A WorthingtonDonald C Goff
May 18, 2020·Psychiatry Research. Neuroimaging·Babak A ArdekaniUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 3, 2019·Schizophrenia Research·Donald C GoffJingping Zhao
Apr 7, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nnamdi NkireJohn L Waddington

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here