Association of Histologic Regression in Primary Melanoma With Sentinel Lymph Node Status: A Systematic Review and Meta-analysis

JAMA Dermatology
Simone RiberoPietro Quaglino

Abstract

The prognostic significance of regression in primary melanoma has been debated for many years. There is no consensus regarding the need for sentinel lymph node (SLN) biopsy when regression is present within the primary tumor. To review the evidence that regression may affect SLN status. A systematic review was performed by searching in MEDLINE, Scopus, and the Cochrane Library from January 1, 1990, through June 2014. All studies that reported an odds ratio (OR) or data on expected and observed cases of SLN positivity and histologic regression were included. Primary random-effects meta-analyses were used to summarize ORs of SLN positivity and histologic regression. Heterogeneity was assessed using the χ2 test and I2 statistic. To assess the potential bias of small studies, we used funnel plots, the Begg rank correlation test, and the Egger weighted linear regression test. The methodologic quality of the studies was assessed according to the Strengthening of Reporting of Observational studies in Epidemiology (STROBE) checklist, and 2 different meta-analyses were performed based on those criteria. Summary ORs of histologic regression of primary melanoma and SLN status. Of the 1509 citations found in the search, 94 articles were re...Continue Reading

Citations

Feb 28, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Phyu P AungVictor G Prieto
Jul 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·A Tejera-VaquerizoE Nagore
Jun 21, 2018·Anais Brasileiros De Dermatologia·Juliana Polizel Ocanha-XavierMariângela Esther Alencar Marques
Jul 13, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·S RiberoC Longo
Jul 10, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A Tejera-VaquerizoE Nagore
Jul 14, 2020·Clinical and Experimental Dermatology·A M CartronA Khachemoune
May 10, 2020·Archives of Dermatological Research·Simone RiberoR Botella-Estrada
Aug 10, 2016·Histopathology·Hala RashedGerald Saldanha
Dec 15, 2018·Journal of Surgical Oncology·David M HyamsAntonio C Buzaid
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Aug 7, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Priyadharsini NagarajanMichael T Tetzlaff
Nov 20, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Priyadharsini NagarajanMichael T Tetzlaff
Jan 1, 2018·Anais Brasileiros De Dermatologia·Juliana Polizel Ocanha-XavierMariângela Esther Alencar Marques
Feb 23, 2021·Laryngoscope Investigative Otolaryngology·Elizabeth KimSamir S Khariwala
Jul 12, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karina AivazianRichard A Scolyer

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