Association of Histone Methyltransferase G9a and Overall Survival After Liver Resection of Patients With Hepatocellular Carcinoma With a Median Observation of 40 Months

Medicine
Kai BaiYi Jiang

Abstract

Approximately 50% of patients with hepatocellular carcinoma (HCC) reside in China. HCC is associated with very high mortality compared with other cancers. Although numerous factors influence the survival of patients with HCC who undergo liver resection, the role of the tumor biomarker histone methyltransferase (G9a) is unknown.We enrolled 350 patients with HCC who underwent liver resection and followed them for 40 months. Patients' clinicopathologic characteristics were acquired from medical records, and overall survival was determined using multiple methods. We conducted an immunohistochemical analysis of study G9a expression in HCC tissues. We used χ test to evaluate the significance of the relationships between G9a and other factors and Cox proportional hazards regression to estimate the hazard ratios and 95% confidence intervals.The levels of alpha-fetoprotein were significantly higher in patients with G9a-positive tumors. TNM stage, elevated alpha-fetoprotein level, and G9a overexpression were associated with worse outcomes.High expression of G9a was associated with worse outcomes, indicating that G9a may serve as a prognostic biomarker for patients with HCC who undergo surgical resection. Because of its role in cell proli...Continue Reading

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Citations

Feb 6, 2017·Molecular Cancer·Tan Boon TohEdward Kai-Hua Chow
Jan 21, 2017·BioMed Research International·Mankgopo M KgatleHenry N Hairwadzi
Aug 5, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Juqiang ZhangMingXin Pan
Dec 22, 2020·European Journal of Pharmacology·Suraya JanSajad Hussain Syed
Oct 15, 2020·Clinical Epigenetics·Theodore VougiouklakisVassiliki Saloura
Feb 9, 2021·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Hong-Lin ChenBin Zhu
Nov 14, 2019·ACS Applied Materials & Interfaces·Mengjie GuEdward Kai-Hua Chow
Nov 4, 2021·Cell Metabolism·Giulia SalvadoriValter D Longo

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.