Association of HIV transmission categories with sociodemographic, viroimmunological and clinical parameters of HIV-infected patients

Epidemiology and Infection
Julio CollazosGrupo Español para el Estudio Multifactorial de la Adherencia (GEEMA)

Abstract

To analyse sociodemographic, viroimmunological and clinical parameters in different HIV-transmission categories at baseline and during treatment, 3039 patients were followed up for 12 months after the initiation of a nelfinavir-based regimen. Multiple baseline parameters were significantly different in the diverse categories, including CD4 counts (P<0.0001) and viral load (P=0.02). There were differences in the groups regarding the CD4 response (P=0.01), but not the virological response (P=0.4), to therapy over time. Multivariate analyses revealed that transmission categories were significantly related to baseline CD4 counts (P=0.01), viral load at 12 months (P=0.0006), poorer adherence to therapy of injecting drug users (IDUs) vs. each of the other groups (P<0.001) and failure to complete the 12-month evaluation of IDU vs. heterosexual (P=0.003) and men who have sex with men (MSM) groups (P=0.02). We conclude that transmission categories had a significant influence on several baseline parameters and viroimmunological outcomes following highly active antiretroviral therapy (HAART), as well as on adherence to therapy and to medical appointments.

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Dec 31, 2015·PloS One·César GarrigaUNKNOWN Barcelona HIV/AIDS working group
Jul 15, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Awachana JiamsakulMatthew Law
May 30, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M DiezC The Hospital Survey Study Group

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