PMID: 15386946Sep 25, 2004Paper

Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province

Biomedical and Environmental Sciences : BES
Ming-Yan XuYi-Ming Shao

Abstract

To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. HLA-B*46 may be associated with its susceptibility to HIV-1 infections.

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