Association of HLA-B27 with ankylosing spondylitis and clinical features of the HLA-B27-associated ankylosing spondylitis: a meta-analysis

Rheumatology International
Hai Lin, Yi-Zhen Gong

Abstract

Many studies have estimated the correlation between HLA-B27 polymorphisms and ankylosing spondylitis (AS). However, the results were controversial. Therefore, we performed this meta-analysis to determine the association of HLA-B*27 polymorphisms with AS and investigate the impacts of HLA-B27 on the clinical symptoms of AS patients. A comprehensive search was performed in PubMed, Web of Science and Embase databases to retrieve the eligible studies, which addressed the association between HLA-B27 polymorphisms and AS susceptibility. The correlation in fixed-effect model was estimated using the relative risk (RR) and 95% confidence intervals (CI). Finally, 41 studies were included in this meta-analysis, among which 35 studies were used to analyze the correlation between HLA-B27 and AS. And 11 studies were applied to estimate the effects of HLA-B27 on the clinical characteristics of AS patients. Besides, our meta-analysis was composed of 8993 AS patients and 19,254 healthy controls. The results suggested that HLA-B27, HLA-B27*02 and HLA-B27*04 were positively in relation to AS (RRHLA-B27 (95% CI) 16.02 (13.85, 18.54), P < 0.001; RRHLA-B*2702 (95% CI) 1.28 (1.08, 1.53), P = 0.005; RRHLA-B27*04 (95% CI) 1.14 (1.01, 1.29), P = 0.041)....Continue Reading

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Citations

Mar 9, 2018·Rheumatology and Therapy·Gergely BodisAndreas Schwarting
May 7, 2019·Molecular Medicine Reports·Xutao FanFengyu Ma
Feb 21, 2021·International Journal of Rheumatic Diseases·Hui YangFaming Pan
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kamal AbdolmohammadiMohammad Hossein Nicknam
Mar 24, 2021·Clinical Rheumatology·Mark C HwangJohn D Reveille
Jul 3, 2021·Journal of Personalized Medicine·Janisleya Silva Ferreira NevesAna Maria Sell
Oct 26, 2021·Frontiers in Cell and Developmental Biology·Zhenyu ZhongPeizeng Yang

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