Association of HLA-DRB1 alleles with susceptibility to mixed connective tissue disease in Polish patients

HLA : Immune Response Genetics
A Paradowska-GoryckaM Jurkowska

Abstract

Mixed connective tissue disease (MCTD) is a systemic autoimmune disease, originally defined as a connective tissue inflammatory syndrome with overlapping features of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM) and systemic sclerosis (SSc), characterized by the presence of antibodies against components of the U1 small nuclear ribonucleoprotein (U1snRNP). The aim of the study was to assess the frequency of (high-resolution-typed) DRB1 alleles in a cohort of Polish patients with MCTD (n = 103). Identification of the variants potentially associated with risk and protection was carried out by comparison with the DKMS Polish Bone Marrow Donor Registry (41306 alleles). DRB1*15:01 (odds ratio (OR): 6.06; 95% confidence interval (CI) 4.55-8.06), DRB1*04 (OR: 3.69; 95% CI 2.69-5.01) and *09:01 (OR: 8.12; 95% CI 2.15-21.75) were identified as risk alleles for MCTD, while HLA-DRB1*07:01 allele was found to be protective (OR: 0.50; 95% CI 0.28-0.83). The carrier frequency of the DRB1*01 was higher in MCTD patients compared with controls, although the differences were not statistically significant. Our results confirm the modulating influence of HLA-DRB1 genotypes on development of conn...Continue Reading

References

Sep 1, 1995·Clinical and Experimental Immunology·S FenningM Schlesier
May 20, 1998·Arthritis and Rheumatism·J S Smolen, G Steiner
Jul 31, 1999·The Journal of Biological Chemistry·M J MamulaP R Blier
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric L GreidingerRobert W Hoffman
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Josephine Swanton, David Isenberg
Apr 26, 2006·Lupus·P J W Venables
Dec 11, 2007·Best Practice & Research. Clinical Rheumatology·Martin Aringer, Josef S Smolen
Apr 29, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Robert W Hoffman, Marcos E Maldonado
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·Oscar-Danilo Ortega-Hernandez, Yehuda Shoenfeld
Mar 22, 2012·Immunologic Research·T CelharA-M Fairhurst
Mar 28, 2013·Pharmacology & Therapeutics·Jing LiHang Yin

❮ Previous
Next ❯

Citations

Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Pravitt GourhElaine F Remmers
Nov 19, 2019·Frontiers in Neurology·Jing ZhaoHongzhi Guan
May 23, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yulei HaoJiachun Feng
Jan 26, 2021·Frontiers in Immunology·Gunnar Houen, Nicole Hartwig Trier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.