Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients

Clinical and Experimental Dermatology
A López-TelloJ Granados

Abstract

Chronic discoid lupus erythematosus (CDLE) is present in 15-30% of patients with systemic lupus erythematosus (SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease. The aim of this study was to determine gene frequencies of HLA-DRB1 alleles in Mexican mestizo patients with CDLE, irrespective of the presence of systemic disease. The study comprised 28 Mexican mestizo patients with CDLE who were attending the Passover Dermatology Centre, in Mexico City. HLA-DRB1 and DQ allele typing was performed by sequence-specific oligotyping after DNA amplification using PCR. The study also included 99 ethnically matched healthy individuals as controls. In the patient group, a significantly increased gene frequency was found for the HLA-DR4 (P = 0.016, OR = 2.24, 95% CI 1.14-4.38) and HLA-DR16 alleles (P = 0.005, OR = 5.51, 95% CI 1.49-21.08). HLA-DRB1 alleles seem to be involved in the genetic susceptibility to CDLE in the Mexican mestizo population.

References

Jun 1, 1990·The British Journal of Dermatology·J KnopH Grosse-Wilde
Oct 1, 1986·American Journal of Physical Anthropology·R LiskerL Buentello
Jan 1, 1985·Journal of the American Academy of Dermatology·J F FowlerP K Cotter
Dec 1, 1994·Human Immunology·G F FischerB Volc-Platzer
May 1, 1996·Journal of the American Academy of Dermatology·L A DrakeD L Tuffanelli
Nov 10, 1998·Scandinavian Journal of Rheumatology·C Bekker-MendezJ Granados
Jul 6, 2004·Clinics in Dermatology·Kyrill D Pramatarov

Citations

Mar 8, 2013·Reumatología clinica·Alicia Habegger de SorrentinoCarlos Baruzzo
Sep 18, 2009·Annals of the New York Academy of Sciences·Carlos VasconcelosBerta Martins
Dec 23, 2011·Arthritis Care & Research·Yesenia Santiago-CasasElizabeth E Brown
Dec 30, 2014·International Journal of Rheumatic Diseases·Zhili NiuYongqing Tong
Jun 26, 2013·Annals of Saudi Medicine·Saleh Al-MotweeAli H Hajeer
Sep 12, 2019·Scientific Reports·Juan Carlos CoronaMarcela Salazar-García

Related Concepts

HLA-DR16 antigen
Alleles
Genetic Equilibrium
Ir Genes
HLA-DR Antigens
Lupus Erythematosus, Discoid
Genetic Predisposition to Disease
HLA-DR Serological Subtypes
HLA-DRB1 antigen

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.

Related Papers

Journal of the European Academy of Dermatology and Venereology : JEADV
H S InalözR J Motley
International Journal of Dermatology
Franck DelesalleEmmanuel Delaporte
Journal of the American Academy of Dermatology
Jae-Hong ParkJoo-Heung Lee
© 2021 Meta ULC. All rights reserved