Association of HLA-G low expressor genotype with severe acute graft-versus-host disease after sibling bone marrow transplantation.

Frontiers in Immunology
Wahid BoukouaciRyad Tamouza

Abstract

Human leukocyte antigen-G (HLA-G) molecules play a prominent role in immune tolerance. Structurally similar to their classical HLA homologs, they are distinct by having high rate of polymorphism in the non-coding regions including a functionally relevant 14-base pair (bp) insertion/deletion (Ins/Del) allele in the 3' untranslated region (3'UTR), rarely examined in a hematopoietic stem cell transplantation (HSCT) setting. Here, we analyzed the potential impact of HLA-G Ins/Del dimorphism on the incidence of acute graft-versus-host disease (aGvHD), transplant-related mortality (TRM), overall survival (OS), and incidence of relapse after HSCT using bone marrow (BM) as stem cell source from HLA-matched donors. One hundred fifty-seven sibling pairs, who had undergone HSCT, were studied for the distribution of the HLA-G 14 bp Ins/Del polymorphism using a polymerase chain reaction (PCR)-based technique. Potential genetic association with the incidence of aGvHD, TRM, and OS was analyzed by monovariate and multivariate analyses. Monovariate analysis showed that the homozygous state for the 14-bp Ins allele is a risk factor for severe aGvHD (grade III and IV; P = 0.008), confirmed subsequently by multivariate analysis [hazard ratio (HR) ...Continue Reading

Citations

Jun 3, 2014·Journal of Affective Disorders·José OliveiraRyad Tamouza
Aug 22, 2014·Journal of Immunology Research·Vera RebmannPeter A Horn
Aug 13, 2015·International Journal of Molecular Sciences·Raffaella FrancaMarco Rabusin
Apr 27, 2017·British Journal of Haematology·Katarzyna Bogunia-Kubik, Piotr Łacina
Oct 9, 2014·Immunological Investigations·Youssef Mohamed Mosaad
Dec 23, 2020·International Journal of Immunogenetics·Katarzyna Bogunia-Kubik, Piotr Łacina
Feb 26, 2020·Human Immunology·Ashwin AjithAnatolij Horuzsko

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Methods Mentioned

BETA
electrophoresis
transgenic

Software Mentioned

Stata
cmprsk
R
SPSS

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