Association of HNPCC and endometrial cancers

International Journal of Clinical Oncology
Kouji BannoShiro Nozawa

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.

Citations

Apr 7, 2007·Familial Cancer·Fabrice LécuruPierre Laurent Puig
Oct 23, 2010·Japanese Journal of Clinical Oncology·Myong Cheol LimSang-Yoon Park
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F LécuruP Laurent-Puig
Nov 30, 2012·Journal of Genetic Counseling·Nicky DekkerMargreet G E M Ausems
Dec 17, 2011·Molecular Biology International·Kenta MasudaDaisuke Aoki
Mar 4, 2008·Gastroenterology Clinics of North America·Tusar K Desai, Donald Barkel

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