Association of homocysteine level with biopsy-proven non-alcoholic fatty liver disease: a meta-analysis

Journal of Clinical Biochemistry and Nutrition
Yining DaiYouming Li

Abstract

Previous studies have reported inconsistent findings regarding the association between plasmatic higher of homocysteine level and non-alcoholic fatty liver disease. We aimed to investigate this association by conducting a meta-analysis. Literature was searched on PubMed from inception to January 2015. Eight studies evaluating plasma level of homocysteine in biopsy-proven non-alcoholic fatty liver disease subjects compared to healthy controls were included. Compared with the controls, non-alcoholic fatty liver disease patients witnessed a higher level of homocysteine [standard mean difference (SMD): 0.66 µmol/L, 95% CI: 0.41, 0.92 µmol/L], and were associated with a significant increased risk for hyperhomocysteinemia [odds ratio (OR) 5.09, 95% CI: 1.69, 15.32]. In addition, patients with non-alcoholic fatty liver presented 0.45 µmol/L higher levels of homocysteine compared to healthy controls (95% CI: 0.09, 0.82 µmol/L), whereas non-alcoholic steatohepatitis patients had 1.02 µmol/L higher levels of homocysteine (95% CI: 0.28, 1.76 µmol/L). There was neither difference of folate level nor vitamin B12 level between non-alcoholic fatty liver disease subjects and healthy controls. This study revealed that non-alcoholic fatty liver ...Continue Reading

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Citations

Sep 20, 2016·Cell Metabolism·Gregory S Ducker, Joshua D Rabinowitz
Dec 5, 2017·Lipids in Health and Disease·Shui-Xian DuWen-Wen Jin
Feb 23, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Liu YaoYi Zhu
May 24, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nur Abu AhmadAron M Troen
Nov 30, 2020·Journal of Clinical Laboratory Analysis·Junfeng ZhangJunfen Fu
Apr 4, 2021·Journal of Clinical Medicine·Mikkel Parsberg WergeLise Lotte Gluud
Apr 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanting YuXiaoyan Wang
Apr 30, 2021·Tzu Chi Medical Journal·Orsu Prabhakar, Mylipilli Bhuvaneswari
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yulia ShulpekovaVladimir Ivashkin
Jul 22, 2021·Arquivos De Gastroenterologia·Débora Silva CostaSabrina Alves Fernandes

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

MOOSE
Stata

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