Association of HPV infection and Chlamydia trachomatis seropositivity in cases of cervical neoplasia in Midwest Brazil

Journal of Medical Virology
Narriman Kennia da Silva BarrosSilvia Helena Rabelo-Santos

Abstract

High-risk human papillomavirus (HPV) is considered the main etiological agent for cervical neoplasia. However, the presence of a single type HPV infection alone is unlikely to be sufficient to cause cervical cancer. There is epidemiologic evidence suggesting that HPV and Chlamydia trachomatis play a central role in the etiology of cervical intraepithelial neoplasia and subsequent cervical cancer. To evaluate the HPV prevalence and the seropositivity for C. trachomatis in women referred to the colposcopy clinic due to an abnormal cervical smear and to examine the effect of this association on the severity of cervical neoplasia. Following enrollment, 131 patients underwent colposcopy and biopsies when necessary. HPV DNA was detected by the polymerase chain reaction (PCR) and genotyping was performed by reverse line-blot hybridization assay. C. trachomatis seropositivity was tested by ELISA for the detection of IgG antibodies. The prevalence of HPV infection was 86.3%. Seropositivity for C. trachomatis was 26%. Thirty-one women (27.4%) were positive for C. trachomatis antibodies and HPV-DNA. The most prevalent HPV type in C. trachomatis-seropositive women were HPV 16 (51.6%) and this HPV type was present mainly in neoplasia cases....Continue Reading

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Citations

May 27, 2015·Journal of Medical Virology·Mariana Magaña-ContrerasErick De la Cruz-Hernandez
Dec 30, 2014·Enfermedades infecciosas y microbiología clínica·María Del Carmen Colín-FerreyraMaría Victoria Domínguez-García
Jul 13, 2016·American Journal of Obstetrics and Gynecology·Dejan R NonatoSilvia H Rabelo-Santos
Jul 24, 2020·Health Care for Women International·Loucine HuckabayErlyana Erlyana
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Naowarat TungsrithongSupannee Promthet
Jul 12, 2017·Frontiers in Public Health·Sally N AdebamowoUNKNOWN ACCME Research Group

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