Association of HSV reactivation and pro-inflammatory cytokine levels with the severity of stomatitis after BEAM chemotherapy and autologous SCT.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Maria J G T RüpingOliver A Cornely

Abstract

Stomatitis, including oral mucositis and ulcerations induced by HSV-reactivation are major sources of morbidity after high-dose (HD) chemotherapy and subsequent autologous hematopoietic stem cell transplantation (SCT). While increased synthesis of pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α)-as well as reactivation of viral infections have frequently been observed in this setting, data on their association with the severity of mucositis is limited. Fifteen patients with Hodgkin's or non-Hodgkin's lymphoma receiving HD conditioning chemotherapy and autologous SCT were assessed with respect to oral pain and severity of stomatitis on day -6, 0, +5 to +7, +13 to +15, and +100. On the same dates, IL-1 and TNF-α were quantified in saliva and screening for a wide range of viral pathogens was carried out by cell culture and PCR and complemented by serological analyses. t Tests were used to assess potential associations between these variables. All but one patient had a positive HSV IgG titer at baseline. Reactivation as confirmed by HSV PCR was observed in seven patients (50%). There was a significant association between the presence of HSV in saliva samples and severity of stomatitis...Continue Reading

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Citations

May 13, 2014·Mediators of Inflammation·T M HavermanF R Rozema
Jul 26, 2018·Brazilian Oral Research·Nayara Fernanda PereiraMaria Gabriela Haye Biazevic
Jul 4, 2017·Deutsche medizinische Wochenschrift·Oliver Andreas Cornely, Sibylle Christiane Mellinghoff
Nov 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sharon EladUNKNOWN Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/Internationa
Oct 22, 2020·Oral Diseases·Andre L F CostaPaulo H Braz-Silva

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