Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell leukaemia (ATL) and in HTLV-I carriers

Clinical Endocrinology
H AkamineM Masuda

Abstract

Human T-lymphotrophic virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukaemia (ATL). This virus is associated with a variety of autoimmune disorders. The possible association between HTLV-I Infection and autoimmune thyroiditis has not been fully studied. We therefore evaluated anti-thyroid peroxidase antibodies (TPOAb) and anti-thyroglobulin antibodies (TGAb) in the sera of patients with ATL, carriers of HTLV-I, and in healthy control subjects to investigate the possible association between such infection and auto-immune thyroiditis. Fifty-two ATL patients (21 males, 31 females; mean age 56.4 years) and 50 HTLV-I carriers (18 males, 32 females; mean age 56.7 years) were studied. The control subjects were 877 healthy adults (271 males, 606 females; mean age 54.8 years) who were negative for HTLV-I antibody. TPOAb, TGAb, thyroxine (T4) and thyrotrophin (TSH) were measured in serum using a radioimmunoassay kit. Positivity for thyroid autoantibodies (TPOAb and/or TGAb) was found in 21 of 52 ATL patients (40.4%), 15 of 50 HTLV-I carriers (30.0%), and 120 of 877 control subjects (13.7%). The difference between the HTLV-I-Infected and the control subjects was statistically significant (P < 0.005). Female control subje...Continue Reading

Citations

Jan 14, 2009·Virology Journal·Rachel Desailloud, Didier Hober
Jun 12, 1998·Nature Medicine·J S Allan
Sep 9, 2005·La Revue de médecine interne·M StrehoR Dhote
Feb 11, 2004·Endocrine Reviews·Luisa BarzonGiorgio Palù
Mar 1, 2008·Expert Review of Clinical Immunology·Nobuyuki Takasu, Jaeduk Yoshimura Noh
Aug 4, 2005·The Journal of Clinical Endocrinology and Metabolism·Takehiro MatsudaNaoki Mori
Mar 7, 2017·International Journal of Rheumatic Diseases·Sanaz Ahmadi GhezeldashtMaryam Sahebari

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