Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope.

PloS One
Hiroshi FurukawaShigeto Tohma

Abstract

Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis (RA) as one of extra-articular manifestations. Many studies for Human Leukocyte Antigen (HLA) allelic association with RA have been reported, but few have been validated in an RA subpopulation with ILD. In this study, we investigated the association of HLA class II alleles with ILD in RA. An association study was conducted on HLA-DRB1, DQB1, and DPB1 in 450 Japanese RA patients that were or were not diagnosed with ILD, based on the findings of computed tomography images of the chest. Unexpectedly, HLA-DRB1*04 (corrected P [Pc] = 0.0054, odds ratio [OR] 0.57), shared epitope (SE) (P = 0.0055, OR 0.66) and DQB1*04 (Pc = 0.0036, OR 0.57) were associated with significantly decreased risk of ILD. In contrast, DRB1*16 (Pc = 0.0372, OR 15.21), DR2 serological group (DRB1*15 and *16 alleles) (P = 0.0020, OR 1.75) and DQB1*06 (Pc = 0.0333, OR 1.57, respectively) were significantly associated with risk of ILD. HLA-DRB1 SE was associated with reduced, while DR2 serological group (DRB1*15 and *16) with increased, risk for ILD in Japanese patients with RA.

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Citations

Nov 10, 2013·BioMed Research International·Lorenzo CavagnaRoberto Caporali
Apr 24, 2014·Annals of the American Thoracic Society·Ivan O RosasFernando J Martinez
May 17, 2014·Rheumatology·Elizabeth PerryDavid Hutchinson
Feb 22, 2013·Current Opinion in Rheumatology·Carl Turesson
Apr 24, 2015·Journal of Human Genetics·Hiroshi FurukawaShigeto Tohma
Sep 24, 2013·Therapeutic Advances in Respiratory Disease·Khanh Vinh Quoc Luong, Lan Thi Hoàng Nguyen
Dec 2, 2015·Therapeutic Advances in Musculoskeletal Disease·Kundan Iqbal, Clive Kelly
Jun 10, 2015·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Hiroshi FurukawaShigeto Tohma
Mar 3, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Megan ShawGanesh Raghu
Sep 4, 2014·PloS One·Dongyi HeXiaodong Zhou
Jan 21, 2017·BMC Musculoskeletal Disorders·Shomi OkaShigeto Tohma
Feb 25, 2021·Current Opinion in Rheumatology·Gregory C McDermottJeffrey A Sparks
Jul 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Hiroshi FurukawaShigeto Tohma
Aug 20, 2021·Seminars in Arthritis and Rheumatism·Pierre-Antoine JugePhilippe Dieudé

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