Association of human papillomavirus infection and abnormal anal cytology among HIV-infected MSM in Beijing, China.

PloS One
Yu YangLei Gao

Abstract

In the recent years, dramatic increases in HIV transmission among men who have sex with men (MSM) have been observed in China. Human papillomavirus (HPV) infection related anal cancer is more common among HIV-infected MSM as compared to the general population. However, HPV infection and anal cytology has been rarely studied in HIV-infected MSM in China. HIV-infected MSM in Beijing, China were invited to participate in this study between January and April 2011. Anal swabs were collected for examining cytology and HPV genotypes. Ninety-five eligible participants with complete questionnaire and laboratory data were included in the analyses. Thirty six of them (37.9%) showed abnormal anal cytology as follows: atypical squamous cells of undetermined significance (ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous intraepithelial lesion (LSIL) in 15 (15.8%), and high-grade squamous intraepithelial lesion (HSIL) in 1 (1.1%). HPV6 (20.0%), HPV16 (10.9%), HPV56 (10.9%), HPV52 (9.1%) and HPV39 (9.1%) were observed most frequently among those with normal anal cytology, while different distribution was found in the ones with abnormal anal cytology as HPV6 (19.4%), HPV16 (19.4%), H...Continue Reading

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Citations

May 8, 2014·PloS One·Dong-Yan ZhangXiang-Sheng Chen
Aug 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jintanat Ananworanich, Anchalee Avihingsanon
Mar 22, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nittaya PhanuphakJoel M Palefsky
Jun 5, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yifei HuSten H Vermund
Jan 9, 2013·Scandinavian Journal of Infectious Diseases·Rebecca LegarthNiels Obel
Aug 23, 2016·PloS One·Chang Hun LeeHong Je Cho

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Methods Mentioned

BETA
genotyping
Enzyme-linked immunosorbent assay

Software Mentioned

Statistical Analysis System ( SAS

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