Association of human platelet antigen polymorphisms with platelet count and mean platelet volume

Hematology
Shihang ZhouMing Liu

Abstract

Although recent genome-wide association studies have identified a number of single nucleotide polymorphisms associated with platelet count and mean platelet volume (MPV), it is unclear whether polymorphisms in the human platelet antigens (HPA) genes are associated with platelet count and MPV. The aim of this study was to determine the association of the HPA-2, -3, -5 and -15 polymorphisms with platelet count and MPV. The HPA were genotyped by 5'-nuclease assay in 139 healthy Chinese Han individuals, while platelet count and MPV from the same samples were measured using an hematology cell analyzer. The platelet count was significantly lower in the individuals with the HPA-2aa genotype compared to those with HPA-2ab (P = 0.020), and significantly higher in individuals with HPA-5aa and HPA-15aa genotypes compared to those with HPA-5ab (P = 0.045) and HPA-15ab/bb (P = 0.032), respectively. On the other hand, platelet count of individuals with the HPA-3aa and HPA-3ab/bb genotypes did not differ significantly (P = 0.084). The MPV was significantly lower in individuals with HPA-5aa genotype compared to those with HPA-5ab (P = 0.001) but did not differ among the HPA-2, -3 and -15 genotypes. Furthermore, HPA-2, -5 and -15 polymorphisms ...Continue Reading

References

Nov 1, 1992·Cancer Metastasis Reviews·K V HonnJ D Crissman
Jan 1, 1990·Journal of Internal Medicine·E D'ErasmoG F Mazzuoli
Jan 1, 1985·Genetic Epidemiology·J B Whitfield, N G Martin
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A PainD J Roberts
Oct 1, 2003·Vox Sanguinis·P MetcalfeS Santoso
Nov 19, 2003·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Scott WilloughbyJoseph Loscalzo
Apr 2, 2005·Circulation Research·Christian Weber
Jun 18, 2005·Genomics·Raymond D MillerUNKNOWN SNP Consortium Allele Frequency Project
Sep 27, 2006·Transfusion Medicine·M L FengT M Zhao
Dec 27, 2008·American Journal of Human Genetics·Christa MeisingerAngela Döring
Feb 25, 2009·Journal of Medical Virology·Camila Fernanda Verdichio-MoraesMaria Inês de Moura Campos Pardini
Aug 21, 2009·Journal of Thrombosis and Haemostasis : JTH·S G ChuJ S Berger
Sep 23, 2009·International Journal of Clinical Practice·L VizioliA Muscari
Nov 19, 2011·Journal of Medical Virology·Giovanni Faria SilvaMaria Inês de Moura Campos Pardini
Dec 6, 2011·Nature·Christian GiegerNicole Soranzo
Oct 10, 2013·Vox Sanguinis·B R Curtis, J G McFarland
Nov 29, 2013·Platelets·Monica VerdoiaUNKNOWN Novara Atherosreclerosis Study Group (NAS)
Apr 23, 2014·Internal Medicine Journal·B LiR-T Wang
Apr 23, 2014·International Journal of Laboratory Hematology·K J Smock, S L Perkins
Mar 15, 2015·Frontiers in Immunology·Hind Hamzeh-CognasseOlivier Garraud

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Citations

Dec 31, 2019·Disease Markers·Katarzyna Brzeźniakiewicz-JanusLidia Gil

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