Association of hypertension with cluster of insulin resistance syndrome factors: the Chennai Urban Population Study (CUPS-12)

Acta Diabetologica
Raj DeepaChennai Urban Population Study (CUPS-12)

Abstract

The objective of this study was to investigate the association of insulin resistance and the cluster of insulin resistance syndrome (IRS) factors with hypertension in a native urban population from southern India. The Chennai Urban Population Study (CUPS) is an epidemiological study involving two residential areas in Chennai in southern India. Of the total of 1399 eligible subjects (age >or=20 years), 1262 (90.2%) participated in the study. Subjects were classified as hypertensives if they had systolic blood pressure (SBP) >or=140 mmHg or diastolic blood pressure (DBP) >or=0 mmHg, if they were known hypertensives, or if they were receiving treatment with antihypertensive drugs. Insulin resistance was computed using the homeostasis model assessment (HOMA IR). The overall prevalence of hypertension in the population was 22.1%. Prevalence of hypertension increased with an increase in quartiles of fasting insulin levels ( p=0.035) and HOMA IR ( p=0.03). Logistic regression analysis revealed that HOMA IR was significantly associated with hypertension, which was not altered even after addition of risk factors like age, smoking habit and alcohol consumption into the model. However, inclusion of variables associated with IRS abolished ...Continue Reading

Citations

May 5, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hye-Sun SeoNamsik Chung
May 24, 2020·Diabetes & Metabolic Syndrome·Maitrayee Mitra, Arnab Ghosh

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