Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study.

BMJ : British Medical Journal
Séverine SabiaArchana Singh-Manoux

Abstract

To examine the association between the Life Simple 7 cardiovascular health score at age 50 and incidence of dementia. Prospective cohort study. Civil service departments in London (Whitehall II study; study inception 1985-88). 7899 participants with data on the cardiovascular health score at age 50. The cardiovascular health score included four behavioural (smoking, diet, physical activity, body mass index) and three biological (fasting glucose, blood cholesterol, blood pressure) metrics, coded on a three point scale (0, 1, 2). The cardiovascular health score was the sum of seven metrics (score range 0-14) and was categorised into poor (scores 0-6), intermediate (7-11), and optimal (12-14) cardiovascular health. Incident dementia, identified through linkage to hospital, mental health services, and mortality registers until 2017. 347 incident cases of dementia were recorded over a median follow-up of 24.7 years. Compared with an incidence rate of dementia of 3.2 (95% confidence interval 2.5 to 4.0) per 1000 person years among the group with poor cardiovascular health, the absolute rate differences per 1000 person years were -1.5 (95% confidence interval -2.3 to -0.7) for the group with intermediate cardiovascular health and -1.9...Continue Reading

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Oct 16, 2019·European Journal of Epidemiology·Nadine BinderMartin Schumacher
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Methods Mentioned

BETA
blood draw

Software Mentioned

mstate
R
FMRIB
FMRIB Software Library
Stata

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