Association of IGF-1 gene rs2195239 polymorphism with the risk and clinical features of gastric cancer in a Chinese Han population.

Journal of Clinical Laboratory Analysis
Pengli Wang, Xiaoyan Zhou

Abstract

Recently, a Japanese study investigated the relationship between insulin-like growth factor-1 (IGF-1) gene rs2195239 polymorphism and gastric cancer (GC) risk and found rs2195239 polymorphism did not relate with the risk of GC. However, no Chinese studies have addressed this relationship until now. Thus, the aims of this study were to demonstrate whether IGF-1 gene rs2195239 polymorphism was linked with the risk and clinical features of GC in a Chinese Han population. In order to verify the link between IGF-1 gene rs2195239 polymorphism and GC risk, we recruited 361 GC cases and 418 controls in this case-control study. The genotyping was done by use of a custom-by-design 48-Plex SNP scan TM Kit. This study found that IGF-1 gene rs2195239 polymorphism decreased the risk of GC. Stratified analyses suggested that the significant association was shown in the females, non-smokers, non-drinkers, and age <60 years groups for GC. In addition, IGF-1 gene rs2195239 polymorphism correlated with the tumor size, tumor clinical stage, and pathological types for GC patients. To sum up, this study shows that IGF-1 gene rs2195239 polymorphism is associated with the risk and clinical features of GC patients in this Chinese population.

References

May 3, 2000·Journal of Mammary Gland Biology and Neoplasia·D L Hadsell, S G Bonnette
Sep 22, 2001·Endocrine-related Cancer·D Sachdev, D Yee
Jun 8, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Nuno LunetHenrique Barros
Feb 23, 2008·Cancer Causes & Control : CCC·Ricardo Ladeiras-LopesNuno Lunet
Mar 20, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Victoria M ChiaKatherine A McGlynn
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brenda M BirmannGraham A Colditz
Sep 3, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fangyi GuPeter Kraft
May 13, 2011·Breast Cancer Research and Treatment·Biyun QianKexin Chen
Jun 22, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ShitaraK Matsuo
Aug 20, 2011·Cancer Epidemiology·Xiaoqun DongDonghui Li
Dec 20, 2013·Lancet·Paolo Vineis, Christopher P Wild
May 10, 2016·Lancet·Eric Van CutsemHans Prenen
Jul 5, 2016·Frontiers in Oncology·Joy ShiHarriet Richardson
Mar 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ShitaraK Matsuo

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