Association of IL -6 -174 G>C polymorphism with the risk of SLE among south Indians: evidence from case-control study and meta-analysis

Lupus
Shiva Krishna KatkamVijay Kumar Kutala

Abstract

Cytokines play a direct role in disease pathogenesis of systemic lupus erythematosus (SLE). Elevated levels of serum IL-6 are well documented with the disease activity and anti-dsDNA antibodies in SLE. The 5' promoter region of the IL-6 gene has been shown to play a significant role in the regulation of gene expression. In view of this, the current study aimed to investigate the possible association of 5' promoter polymorphisms G-597A (rs1800797), G-572C (rs1800796) and G-174C (rs1800795) with the risk of SLE. Analysis of 468 subjects (202 SLE patients and 266 controls) showed a significant association of the -174 G/C variant with the SLE risk in both dominant and recessive model (odds ratio (OR) 3.20, 95% confidence interval (CI) 1.18-8.69, P = 0.020 and OR 2.02, 95% CI 1.35-3.02, P = 0.0005), respectively. The 'G allele of the -174 loci (OR 1.97, 95% CI 1.39-2.78, P = 0.00012) has shown significant distribution between the cases and controls. The haplotype analysis revealed that AGG haplotype carriers are more frequent in cases than controls and found a significant positive association (OR 1.394, 95% CI 1.07-7.12, P = 0.028) with SLE. In addition, we also undertook a meta-analysis on 13 study groups for -174 G/C, comprising a...Continue Reading

References

Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Nov 1, 1988·European Journal of Immunology·T HiranoM Feldmann
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
Aug 1, 1994·The Journal of Clinical Investigation·B K FinckD Wofsy
Apr 5, 2000·The Journal of Biological Chemistry·C F TerryF R Green
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Aug 19, 2003·Shock·Fernando A Rivera-ChavezGrant E O'Keefe
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Aug 23, 2007·Tissue Antigens·P Guarnizo-ZuccardiG Vasquez
Feb 9, 2008·Arthritis Research & Therapy·Olli-Pekka KämäräinenPäivi Leino-Arjas
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soizic GaraudYves Renaudineau
May 19, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K H ChuaL H Lian
Apr 13, 2010·Clinical Rheumatology·Esmaeil Moazemi GodarziZahra Amirghofran
Dec 15, 2010·European Journal of Cell Biology·Athena ChalarisJürgen Scheller
Apr 5, 2011·Arthritis Research & Therapy·Vaishali R Moulton, George C Tsokos
Jul 13, 2011·Arthritis Research & Therapy·Noam Jacob, William Stohl
Sep 2, 2011·The Journal of Clinical Investigation·Simon A JonesStefan Rose-John
Jul 4, 2012·The Journal of Experimental Medicine·Cindy S MaStuart G Tangye
Nov 9, 2012·International Journal of Biological Sciences·Stefan Rose-John

❮ Previous
Next ❯

Citations

Mar 5, 2019·Developmental Science·Tashauna L BlankenshipMartha Ann Bell
Apr 16, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Alissa KnowlesElizabeth Cauffman
Nov 28, 2019·Autoimmunity·Farhana Muhammad YusoffNorhanani Mohd Redzwan
Jan 19, 2021·Immunological Investigations·Qian WuAn-Fang Huang
Jul 21, 2020·Clinical and Experimental Pediatrics·Seoung Wan NamAndreas Kronbichler

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA
biopsy

Software Mentioned

Shesis
Primer3
Assembler
Ensemble
Vassar Stats Calculator
CMA
BLAST
FinchTV
Primer
Google Scholar

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.