Abstract
Chronic rhinosinusitis (CRS) is one of the most common and complex chronic inflammatory disease of sinonasal mucosa. Even though the pathogenesis of CRS is multifactorial and still unclear, the role of cytokines especially interleukin-1 (IL-1) is being investigated worldwide in different population because of varying results obtained. To study the association of IL-1 (A and B) gene polymorphisms with chronic rhinosinusitis with nasal polyp (CRSwNP) and without nasal polyp (CRSsNP), and other factors related. This is a case-controlled study which include a total of 138 subjects recruited from Otorhinolaryngology-Head and Neck Surgery clinic in Hospital Universiti Sains Malaysia. Genotyping of the IL-1A (+4845G, +4845T) and IL-1B (-511C, -511T) were performed with restriction fragment length polymorphism analysis. There was a statistical significant association between IL-1B (-511C, -511T) polymorphism with CRSwNP and CRSsNP (p < 0.001). The CT genotype of IL-1B was markedly increased in CRSwNP subjects (52.2%). However, there was no significant association found between IL-1A (+4845G, +4845T) with CRSwNP and CRSsNP (p = 0.093). No association was found in factors related to CRS, which included asthma, atopy, allergy, aspirin sen...Continue Reading
References
Jun 1, 1990·Gut·M LigumskyD Rachmilewitz
Jan 1, 1973·Annals of Internal Medicine·R F LockeyN A Vanselow
Nov 25, 1995·BMJ : British Medical Journal·V J Lund
Dec 31, 1998·Arthritis and Rheumatism·B BresnihanP Musikic
Aug 12, 1999·Allergy·M F Kramer, G Rasp
May 20, 2003·Allergy·J KarjalainenM Hurme
Mar 22, 2006·Archives of Otolaryngology--head & Neck Surgery·Yuan-Kai ChengFuu-Jen Tsai
Feb 8, 2007·American Journal of Rhinology·Aleena BanerjiDaniel L Hamilos
Jul 20, 2007·Archives of Otolaryngology--head & Neck Surgery·Selim S ErbekOzcan Cakmak
May 1, 2009·The Laryngoscope·Joel M BernsteinLara Sucheston
Feb 17, 2010·Archives of Otolaryngology--head & Neck Surgery·Leandra Mfuna EndamMartin Desrosiers
May 25, 2011·Allergy·D HastanP Burney
Apr 4, 2012·Rhinology·Wytske J FokkensPeter John Wormald
Aug 1, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Claus BachertPhilippe Gevaert
Feb 28, 2014·International Forum of Allergy & Rhinology·Kevin HurSandra Y Lin
Apr 4, 2014·Current Opinion in Otolaryngology & Head and Neck Surgery·Kent LamBruce K Tan
Jan 30, 2015·Allergy·J B ShiG Xu
Jan 31, 2015·Current Opinion in Rheumatology·Alexandre Dumusc, Alexander So
Apr 4, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Atsushi Kato
May 16, 2015·American Journal of Rhinology & Allergy·Matthew LamRichard J Harvey
Jan 24, 2016·Current Allergy and Asthma Reports·Derrick TintElina Toskala
Apr 13, 2017·Brazilian Journal of Otorhinolaryngology·Vanessa Ramos Pires DinarteWilma Terezinha Anselmo-Lima
Apr 30, 2017·Clinical and Experimental Otorhinolaryngology·Khairunnisak MisronRamiza Ramza Ramli
Mar 30, 2018·Frontiers in Immunology·Petra ZimmermannNicole Ritz