Association of IL-1R2 genetic polymorphisms with the susceptibility of ankylosing spondylitis in Northern Chinese Han population

Modern Rheumatology
Yu XiaYue-Ran Zhao

Abstract

Previous Genome-wide association studies (GWAS) have demonstrated Interleukin-1 receptor 2 (IL-1R2) was strongly associated with susceptibility to ankylosing spondylitis (AS). The aim of this study was to replicate the association of IL-1R2 single-nucleotide polymorphisms (SNPs) with AS in the northern Han Chinese. A total of 490 AS patients and 580 matched healthy controls were enrolled in our study. Six tagSNPs in IL-1R2: rs4851526, rs4851527, rs2302589, rs2072476, rs2072472, and rs2310173 were selected and genotyped by Taqman SNP genotyping method. The differences of allele and genotype frequencies were analyzed by use of PLINK 1.07. Logistic regression analysis showed that one tagSNP rs2302589 in IL-1R2 was significantly associated with AS susceptibility (OR 0.77, 95% CI = 0.64-0.92, P = 0.005). However, no significant association was observed on the other tagSNPs for AS risk. The haplotype analysis further showed that the haplotype "GCGCGG" of IL-1R2 was also associated with the increased risk of AS (OR 1.362, P = 0.0207). This is the first detection that the genetic variation rs2302589 in IL-1R2 gene was associated with AS in Northern Han Chinese. This result confirmed that IL-1R2 may be genetic biomarker for susceptibili...Continue Reading

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Citations

Dec 17, 2017·Immunological Reviews·Diana BoraschiMichael U Martin
Dec 5, 2017·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Wen-Feng RuanAn-Song Ping
Sep 27, 2018·The Journal of Gene Medicine·Guoxia RenMingwei Chen
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Jul 7, 2019·Annals of the Rheumatic Diseases·Dennis G McGonagleRobert Moots
Mar 22, 2019·Molecular Genetics & Genomic Medicine·Jiamin WuTianbo Jin
Dec 9, 2020·Journal of Vestibular Research : Equilibrium & Orientation·Eun Hye OhJae-Hwan Choi
Jun 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Negar VanakiMahdi Mahmoudi

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