Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis

PloS One
Lucia Elena Alvarado-ArnezMilton Ozório Moraes

Abstract

Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine in mycobacterial pathogenesis and especially the -819C>T SNP (rs1800871) has been tested in several case-control studies indicating association with leprosy risk, although a recent consensus estimate is still missing. In this study, we evaluated the association of the -819C>T SNP and leprosy in two new Brazilian family-based populations. Then, we performed meta-analysis for this polymorphism summarizing published studies including these Brazilian family-based groups. Finally, we also retrieved published studies for other distal and proximal IL10 polymorphisms: -3575 T>A (rs1800890), -2849 G>A (rs6703630), -2763 C>A (rs6693899), -1082 G>A (rs1800896) and -592 C>A (rs1800872). Results from meta-analysis supported a significant susceptibility association for the -819T allele, with pooled Odds Ratio of 1.22 (CI = 1.11-1.34) and P-value = 3x10(-5) confirming previous data. This result remained unaltered after inclusion of the Brazilia...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Mar 29, 2000·Scandinavian Journal of Immunology·M C LimaM C Pessolani
Oct 31, 2000·Genetic Epidemiology·N M LairdX Xu
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A W GibsonR P Kimberly
Apr 3, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E RandallP E M Fine
Nov 26, 2002·The Journal of Infectious Diseases·Adalberto R SantosEuzenir N Sarno
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
Apr 23, 2005·Annals of Human Genetics·G R Kazeem, M Farrall
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Oct 20, 2009·Cell Host & Microbe·Dennis MontoyaRobert L Modlin
May 18, 2011·Infection and Immunity·Joshua C Cyktor, Joanne Turner
May 19, 2011·Future Microbiology·Cynthia Chester CardosoMilton Ozório Moraes
Aug 23, 2012·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Maria Glória TeixeiraEduardo Hage Carmo
Nov 7, 2012·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean
Aug 24, 2013·Clinical and Vaccine Immunology : CVI·Patricia GarciaSidney Santos
Sep 26, 2013·Genetics and Molecular Research : GMR·X H ChenJ C Gu

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Citations

May 21, 2020·PLoS Neglected Tropical Diseases·André Luiz LeturiondoCarolina Talhari
Dec 22, 2016·Mediators of Inflammation·Adriana Antônia da Cruz FuriniRicardo Luiz Dantas Machado
May 7, 2020·Frontiers in Immunology·Zihao MiFuren Zhang
Jan 30, 2020·Scientific Reports·Priscila Verchai Uaska SartoriMarcelo Távora Mira
Nov 13, 2019·Human Genetics·Vinicius M FavaErwin Schurr
May 20, 2021·Frontiers in Tropical Diseases·Alfonso J Rodriguez-MoralesJose A Suárez

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

meta
1000
StepOne real - time system
Haploview
catmap
genetics
FBAT
tdthap
R

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