Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein

Scientific Reports
Anna ZettergrenHenrik Zetterberg

Abstract

A possible involvement of the gene IL1RAP (interleukin-1 receptor-associated protein) in the pathogenesis of Alzheimer's disease (AD) has been suggested in GWASs of cerebrospinal fluid (CSF) tau levels and longitudinal change in brain amyloid burden. The aim of this study was to examine previously implicated genetic markers in and near IL1RAP in relation to AD risk, CSF tau and Aβ biomarkers, as well as cognitive decline, in a case (AD)-control study and an age homogenous population-based cohort. Genotyping of IL1RAP-related single nucleotide polymorphisms (SNPs), selected based on previous GWAS results, was performed. 3446 individuals (1154 AD cases and 2292 controls) were included in the analyses of AD risk, 1400 individuals (cognitively normal = 747, AD = 653) in the CSF biomarker analyses, and 861 individuals in the analyses of cognitive decline. We found no relation between IL1RAP-related SNPs and AD risk. However, CSF total-tau and phospho-tau were associated with the SNP rs9877502 (p = 6 × 10-3 and p = 5 × 10-4). Further, nominal associations (p = 0.03-0.05) were found between three other SNPs and CSF biomarker levels, or levels of cognitive performance and decline in a sub-sample from the general population. These resul...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1971·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·F D'Ermo, L Bonomi
Dec 1, 1995·Molecular and Chemical Neuropathology·K BlennowE Vanmechelen
Oct 16, 2007·Teaching and Learning in Medicine·Claudio Violato, Kent G Hecker
Jan 1, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Madeleine ZetterbergHenrik Zetterberg
Feb 24, 2010·Nature Reviews. Rheumatology·Cem GabayGaby Palmer
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 31, 2010·Nature Immunology·Dongli WangXinquan Wang
Sep 29, 2011·Nature Neuroscience·Marco PrinzRichard M Ransohoff
Oct 28, 2011·Nature·Hyo Jung KangNenad Sestan
Nov 8, 2011·Neurobiology of Aging·Philip L De JagerDenis A Evans
Apr 5, 2012·Current Alzheimer Research·David A BennettRobert S Wilson
Apr 14, 2012·Journal of Neuroimmunology·Spencer Luiz Marques PayãoMarília de Arruda Cardoso Smith
May 19, 2012·Human Molecular Genetics·Anbarasu LourdusamyUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 15, 2012·Journal of Alzheimer's Disease : JAD·Bob OlssonOskar Hansson
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simantini GhoshM Kerry O'Banion
Jul 3, 2015·Brain : a Journal of Neurology·Tobias SkillbäckHenrik Zetterberg
Aug 14, 2015·Brain : a Journal of Neurology·Vijay K RamananUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Nov 4, 2015·Brain, Behavior, and Immunity·Fan SuZhijun Zhang
Sep 19, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Anna ZettergrenIngmar Skoog
Mar 24, 2018·Neuron·Chihiro SatoRandall J Bateman
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors

❮ Previous
Next ❯

Citations

Feb 2, 2021·Journal of Alzheimer's Disease : JAD·Ana MacedoNádia Pinto

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.