Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia

Journal of Hypertension
Xuan ShaoYan-Ling Wang

Abstract

Preeclampsia, a serious pregnancy-associated syndrome, is the leading cause of maternal and perinatal morbidity and mortality. Significant exacerbation of the hypercoagulation status as well as imbalanced steroid hormones have been reported in developed preeclampsia. However, it remains unclear whether the two pathological changes are directly associated. Our proteomic analysis revealed a significantly elevated SerpinF2/α2-antiplasmin level in preeclampsia plasma. Measurement of the longitudinally gestational change of plasmin-α2-antiplasmin (PAP) complex, testosterone, estradiol in preeclampsia patients and normal pregnant women demonstrated that the circulating PAP and testosterone levels in the early-onset preeclampsia (E-PE) patients were substantially higher, whereas estradiol concentration was significantly lower than that in normal pregnant controls from early pregnancy throughout gestation. Correlation analysis revealed that circulating PAP is in positive correlation with the concentration of testosterone, and in negative correlation with estradiol in E-PE patients. In E-PE placenta, the productions and activities of 17β-hydroxysteroid dehydrogenases 3 and aromatase, the essential enzymes for testosterone and estradiol ...Continue Reading

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Citations

Mar 23, 2021·Human Reproduction Update·María M PereiraJerome F Strauss
Sep 24, 2020·The Journal of International Medical Research·Jianxia HuangPei He
Jan 6, 2022·Journal of Animal Science·Hiruni R WijesenaClay A Lents

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